https://bbs.sific.com.cn/thread-95937-1-1.html
这是“蓝鱼o_0 ”老师的帖子“我们都知道S。A（金黄色葡萄球菌）的定植是SSTI（皮肤软组织感染）的重要危险因素。那么通过去定植，如莫匹罗星，或者洗必泰进行去定植即可以降低SSTI的发病风险。
然后细菌时很聪明的，随时都在进化，那么多久可以携带耐药基因呢？”
相关回答如下：
摘要
24 Decolonization measures, including mupirocin and chlorhexidine, are often prescribed
25 to prevent Staphylococcus aureus skin and soft tissue infections (SSTI). The objective
26 of this study was to determine the prevalence of high-level mupirocin and chlorhexidine
27 resistance in S. aureus strains recovered from patients with SSTI before and after
28 mupirocin and chlorhexidine administration, and to determine whether carriage of a
29 mupirocin- or chlorhexidine-resistant strain at baseline precluded S. aureus eradication.
30 We recruited 1089 patients with community-onset SSTI ± S. aureus colonization. In
31 addition to routine care, 483 patients were enrolled in a decolonization trial: 408
32 received intranasal mupirocin (with or without antimicrobial baths), and 258 performed
33 chlorhexidine body washes. Patients were followed for up to 12 months with repeat
34 colonization cultures. 他们随访了12个月。所有的金葡萄菌都检测莫匹罗星和洗必泰耐药基因。All S. aureus isolates were tested for high-level mupirocin and
35 chlorhexidine resistance. At baseline, 23/1089 (2.1%) patients carried a mupirocin36
resistant S. aureus strain and 10/1089 (0.9%) patients carried chlorhexidine-resistant S.
37 aureus. Of 4 patients prescribed mupirocin who carried a mupirocin-resistant S. aureus
38 strain at baseline, 100% remained colonized at 1 month用药一个月后，莫匹罗星耐药基因携带100%, compared to 44% of the 324
39 patients without mupirocin resistance at baseline (p=0.041). Of 2 patients prescribed
40 chlorhexidine who carried a chlorhexidine-resistant S. aureus strain at baseline, 50%
41 remained colonized at 1 month, compared to 48% of the 209 patients without
42 chlorhexidine resistance at baseline (p=1.0)（洗必泰使用一个月后这种携带不明显。但是这种样本量似乎太小了点）. The overall prevalence of mupirocin and
43 chlorhexidine resistance is low in S. aureus isolates recovered from outpatients but
44 eradication efforts were less successful in patients carrying a mupirocin-resistant S.
45 aureus strain at baseline.
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发表于 2016-7-13 09:17
