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题目Neutrophils Engraftment Delay During TigecyclineTreatment in 2 Bone Marrow–transplanted Patients Background: Tigecycline is the first available drug of glycylcycline family. Because of recent introduction, some of its adverse effects could be still unexplored. Observation: We report the cases of 2 boys who underwent an allogenic bone marrow transplantation for acute myeloid leukemia and were treated with tigecycline. Erythrocyte and platelet engraftment followed a normal course, but the neutrophil count remained low despite the increase in leukocyte count. After tigecycline interruption, the neutrophil count rapidly raised in both cases. Conclusions: Neutropenia was suspected to be secondary to tigecycline exposure. In vitro experiments were performed, which
suggested tigecycline influence on myeloid cells survival.
发表于 2013-2-12 06:46
发表于 2013-2-17 15:49
