替加环素治疗骨髓移植多重耐药菌感染

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替加环素治疗多重耐药菌感染

P23171996替加环素治疗骨髓移植.pdf (340.62 KB, 下载次数: 9)

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题目Neutrophils Engraftment Delay During TigecyclineTreatment in 2 Bone Marrow–transplanted Patients
Background: Tigecycline is the first available drug of glycylcycline family. Because of recent introduction, some of its adverse effects could be still unexplored.
Observation: We report the cases of 2 boys who underwent an allogenic bone marrow transplantation for acute myeloid leukemia and were treated with tigecycline. Erythrocyte and platelet engraftment followed a normal course, but the neutrophil count remained low despite the increase in leukocyte count. After tigecycline interruption, the neutrophil count rapidly raised in both cases.
Conclusions: Neutropenia was suspected to be secondary to tigecycline exposure. In vitro experiments were performed, which
suggested tigecycline influence on myeloid cells survival.

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谢谢楼主提供的资料。如果朱老师将贴出的摘要翻译成中文就更好了。让更多的会员受益！