September 19, 2008 — Maternal immunization with inactivated influenza vaccine is associated with a 63% reduction in laboratory-confirmed influenza and a 29% reduction in respiratory tract illness with fever in infants up to 6 months old, according to the results of a randomized controlled, blinded trial reported in the September 16 Online First issue of the New England Journal of Medicine.
2008/9/18-在9月16日新英格兰杂志网络首发的单盲法报道称，按照随机控制结果，用灭活的流感疫苗给孕产妇免疫，与减少63％的实验室证实流感和29％的6个月内发热婴幼儿呼吸道疾病相关。
"Young infants and pregnant women are at increased risk for serious consequences of influenza infection," write K. Zaman, MB, BS, PhD, from the International Centre for Diarrheal Disease Research in Dhaka, Bangladesh, and colleagues.
“婴幼儿和怀孕妇女患流感的严重结果的风险增加，”来自Dhaka腹泻疾病研究国际中心的K. Zaman, MB, BS, PhD和他的同事们写道。
In this study, 340 pregnant women in the third trimester were randomly assigned to receive inactivated influenza vaccine or the 23-valent pneumococcal polysaccharide vaccine (control). Mothers were interviewed weekly about signs of illness in themselves or their infants from birth to 24 weeks. Participants with febrile respiratory tract illness were examined clinically, and ill infants were tested for influenza antigens. Outcomes included respiratory tract and other illnesses, incidence rate ratios, and vaccine effectiveness.
在这个研究中，340名孕妇在孕期第三个三个月中被随机的分配接受灭活流感疫苗或者23－价肺炎球菌多糖疫苗注射（对照）。每周访问一次母亲,观察她们自身的疾病信号或者她们自出生到24周的婴儿。伴有发热的呼吸道疾病的参与者做临床检查，测定患病婴儿的流感抗原。结果包括呼吸道和其它的疾病，发病率的比例和疫苗效价。
Compared with infants in the control group, those born to mothers who received influenza vaccine had fewer cases of laboratory-confirmed influenza, with a vaccine effectiveness of 63% (95% confidence interval [CI], 5% - 85%).
与对照组的婴儿相比，母亲接受流感疫苗出生的婴儿患实验室确认的流感感染较少，63%具有疫苗效力（95％可信区间，5％－85％）。
For preventing respiratory tract illness with fever, maternal vaccine effectiveness in infants was 29% (95% CI, 7% - 46%). Mothers vaccinated against influenza had a 36% reduction in the rate of respiratory tract illness with fever (95% CI, 4% - 57%). The rate of diarrheal illness was similar in both study groups.
预防伴发热的呼吸道疾病，在婴儿，继承母体的疫苗效力为29％（95％CI，7％－46％）。伴发热的呼吸道疾病的母亲流感免疫呈36％的降低（95％CI，4% - 57%）。腹泻性疾病的发病率在两组中相像。
Limitations of this study include lack of data on prevalent influenza strains, insufficient power to assess the infrequent outcomes of influenza, and testing of only some of the infants for influenza.
这个研究的局限包括缺乏预防流感株的数据，评估罕见型流感的结果能力不足和仅仅对其中的一些患流感的患儿做检测。
"Inactivated influenza vaccine reduced proven influenza illness by 63% in infants up to 6 months of age and averted approximately a third of all febrile respiratory illnesses in mothers and young infants," the study authors conclude. "Maternal influenza immunization is a strategy with substantial benefits for both mothers and infants."
“灭活的流感疫苗减少63％6个月内婴儿患可被证实的流感，防止大约1/3的母亲和婴儿患伴发热的呼吸道疾病，”研究作者总结。“母亲的流感免疫是一条途径，它可以使的母亲和婴儿相当程度的获益。
The Bill and Melinda Gates Foundation, USAID, HHS, the Thrasher Research Fund, National Vaccine Program Office, Wyeth, Aventis Pasteur, Johns Hopkins University, and the International Centre for Diarrheal Disease Research supported this study. Some of the study authors have disclosed various financial relationships with the Bill and Melinda Gates Foundation, USAID, Merck, GlaxoSmithKline, and/or sanofi aventis.
此项工作受比尔.盖茨和梅林达.盖茨基金会，USAID,HHS, Thrasher研究基金会，国立疫苗工程办公室，惠氏，安万特.帕斯特，约翰霍普金斯大学和腹泻性疾病研究国际中心支持。一些作者透露与比尔.盖茨和梅林达.盖茨基金会，USAID,默克，葛兰素史克和/或赛诺菲安万特存在多种资金关系。
N Engl J Med. Published online September 16, 2008.摘自<丁香园>谢谢提供者! |
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