社区获得性MRSA致病因子的作用（PVL不是唯一的）

David

Trends in Microbiology
Volume 16, Issue 8, August 2008, Pages 361-369

Opinion
The role of virulence determinants in community-associated MRSA pathogenesis
社区获得性MRSA致病因子的作用（PVL不是唯一的）
Binh An Diep1 and Michael Otto2,

1Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, 1001 Potrero Avenue, Box 0811, San Francisco, CA 94110, USA 2National Institute of Allergy and Infectious Diseases, The National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
Available online 26 June 2008.

The recent emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) marked a quantum change in the biology and epidemiology of a major human pathogen. Various virulence determinants unique to CA-MRSA have been uncovered recently, which shed light on how these strains spread easily and sustainably among humans and frequently cause severe disease. The role of the Panton Valentine leukocidin (PVL) in CA-MRSA pathogenesis is a matter of much debate. Although epidemiological data have indicated a role for PVL in the CA-MRSA disease process, recent data from relevant animal models indicate that PVL does not impact virulence of prevalent CA-MRSA strains. (尽管流行病学数据表明PVL在CA-MRSA感染发病过程中起到相关作用，但动物模型却表明PVL不影响CA-MRSA流行株的致病力。)Identifying specialized pathogenic traits of CA-MRSA remains a challenge that will yield new diagnostic tools and therapeutic targets for drug and vaccine development. Here, we discuss the roles of PVL, the arginine catabolic mobile element and phenol-soluble modulins in the pathogenesis of prevalent CA-MRSA strains.

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he specific pathogenic traits of other prevalent CA -MRSA strains ,including ST30,ST59 and ST80 ,will need to be identified  and  their relative contributions to the disease process  elucidated to  prioritize targets for drug and vaccine development.