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耐碳青霉烯铜绿情况有奖调查

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发表于 2012-3-7 13:14 | 显示全部楼层 |阅读模式

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最近,《医院感染预防与控制最佳实践丛书》正在紧张地进行中。根据专家审稿意见,《多重耐药》分册需要补充多重耐药菌在各个地区或国家所占的百分比的最新资料。因此,需要查阅大量文献,特开此贴,有奖征集相关的文献。

本贴调查耐碳青霉烯铜绿占铜绿的比例,共需要收集美国、英国、日本、印度和中国的数据。

文献要求:以大型监测数据或多中心流调为主,尽量查阅最新的数据,目前应该以2009年或2010年的数据为主,2011年的数据肯定还没有发表成文。将文献题目、摘要、发表期刊、年份及相关的“耐碳青霉烯铜绿占铜绿的比例”的数据以回贴的形式发出。

欢迎大家积极参与本活动,加分鼓励,谢谢!

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 楼主| 发表于 2012-3-11 10:56 | 显示全部楼层
J Antimicrob Chemother. 2008 Nov;62 Suppl 2:ii55-63.
Non-susceptibility trends among Pseudomonas aeruginosa and other non-fermentative Gram-negative bacteria from bacteraemias in the UK and Ireland, 2001-06.
Livermore DM, Hope R, Brick G, Lillie M, Reynolds R; BSAC Working Parties on Resistance Surveillance.
SourceHealth Protection Agency Centre for Infections, 61 C olindale Avenue, London NW9 5EQ, UK. david.livermore@hpa.org.uk

Abstract
BACKGROUND: Pseudomonas and Acinetobacter spp. are important opportunists, notorious for resistance. Pseudomonas spp. are collected in the British Society for Antimicrobial Chemotherapy (BSAC) bacteraemia surveillance, with Acinetobacter spp. and Stenotrophomonas maltophilia well represented in the 'other Gram-negatives' group.

METHODS: Data for collected isolates were reviewed together with LabBase bacteraemia reports to the Health Protection Agency (HPA). Isolates with unusual resistances were subjected to molecular investigation.

RESULTS: From 2001 to 2006, the BSAC surveillance collected 1226 Pseudomonas aeruginosa, 240 Acinetobacter spp.-125 of them Acinetobacter calcoaceticus/baumannii (Acb) complex-and 165 S. maltophilia. Among P. aeruginosa, non-susceptibility rates to beta-lactams and gentamicin fluctuated, without trend, below 10%; those to ciprofloxacin ranged from 16% to 22%. One P. aeruginosa isolate from 2001 had VIM-2 metallo-beta-lactamase. For Acb, the BSAC data indicated frequent non-susceptibility, except to imipenem, where only five non-susceptible isolates were collected, all after 2003, four of them belonging to the OXA-23 clone 1 lineage which is prevalent in Southeast England. Reports to the HPA indicated rising imipenem non-susceptibility in Acb (P < 0.0001). Co-trimoxazole retained near-universal activity against S. maltophilia. Among new antibiotics, doripenem MICs were </=4 mg/L for most imipenem-resistant P. aeruginosa but >/=16 mg/L for Acb OXA-23 clone 1. Ceftobiprole had higher MICs than ceftazidime for P. aeruginosa, but 81% of the isolates were inhibited at </=4 mg/L. Tigecycline had activity against most Acb, including OXA-23 clone 1, and also against S. maltophilia.

CONCLUSIONS: Most P. aeruginosa from bacteraemias in the UK and Ireland remain relatively susceptible by international standards; in contrast, multiresistance is widespread in Acb, with imipenem non-susceptibility emerging.

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