Emergence of resistance in Shigella flexneri subserotype 1c

细菌耐药

Clin Microbiol Infect. 2012 Jan 13. doi: 10.1111/j.1469-0691.2012.03768.x. [Epub ahead of print]

Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China.

Qiu S, Xu X, Wang Y, Yang G, Wang Z, Wang H, Zhang L, Liu N, Chen C, Liu W, Li J, Su W, Jia L, Wang L, Jin H, Keim P, Yuan Z, Huang L, Song H.
Source Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China  Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China  Chenggong Hospital affiliated to Xiamen University, Xiamen, China,  MGGen, Northern Arizona University, Flagstaff, AZ, USA.

Abstract
Clin Microbiol Infect ABSTRACT: We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first time. Isolates of seven strains circulating in China yielded three new sequence types and seven pulsed-field gel electrophoresis patterns, thus demonstrating the existence of high genetic diversity within the isolates. Overall, the seven isolates showed reduced susceptibility to ciprofloxacin; one isolate was ciprofloxacin resistant, whilst another developed resistance to ciprofloxacin, norfloxacin, cefotaxime and ceftriaxone.

© 2012 The Authors Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.