台湾β内酰胺类高水平耐药的肺炎链球菌克隆传播

David

Antimicrobial Agents and Chemotherapy, June 2008, p. 2266-2269, Vol. 52, No. 6

Clonal Spread of Highly β-Lactam-Resistant Streptococcus pneumoniae Isolates in Taiwan
台湾β内酰胺类高水平耐药的肺炎链球菌克隆传播
Yu-Chia Hsieh,1 Kuang-Yi Chang,2,3 Yi-Chuan Huang,4 Hsiao-Chuan Lin,5 Yu-Huai Ho,6 Li-Min Huang,7* and Po-Ren Hsueh8*
Section of Infection, Department of Medicine, Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan,1 Division of Biostatistics, College of Public Health, National Taiwan University, Taipei, Taiwan,2 Department of Anesthesiology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan,3 Division of Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan,4 Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan,5 Department of Pediatrics, Buddhist Tzu Chi General Hospital, Hualien, Taiwan,6 Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan,7 Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan8

Received 13 January 2008/ Returned for modification 10 February 2008/ Accepted 3 April 2008

This study aimed to evaluate the antimicrobial susceptibility profiles of 364 Streptococcus pneumoniae isolates and studied the genotypes of S. pneumoniae with high level β-lactam resistance in Taiwan. Clonal complexes related to Spain23F-1, Taiwan19F-14, and Taiwan23F-15 were responsible for the spread of isolates with high β-lactam resistance.