A Comprehensive Survey of Single Nucleotide Polymorphisms (SNPs) across

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A Comprehensive Survey of Single Nucleotide Polymorphisms (SNPs) across Mycobacterium bovis Strains and M. bovis BCG Vaccine Strains Refines the Genealogy and Defines a Minimal Set of SNPs That Separate Virulent M. bovis Strains and M. bovis BCG Strains

M. Carmen Garcia Pelayo,1‡ Swapna Uplekar,2‡ Andrew Keniry,3§ Pablo Mendoza Lopez,1,4
Thierry Garnier,5 Javier Nunez Garcia,1 Laura Boschiroli,6 Xiangmei Zhou,7 Julian Parkhill,3
Noel Smith,1,8 R. Glyn Hewinson,1 Stewart T. Cole,2 and Stephen V. Gordon1,9,10,11,12*
TB Research Group, VLA Weybridge, New Haw, Surrey KT15 3NB, United Kingdom1; Global Health Institute, EPFL, CH-1015 Lausanne,
Switzerland2; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom3;
Department of Biochemistry and Molecular Biology, Universidad de Granada, Granada, Spain4; Unite´ deGe´ne´tique et Ge´nomique des
Insectes Vecteurs, Institut Pasteur, 28 Rue du Dr Roux, Paris 75015, France5; Agence Franc¸aise de Se´curite´ Sanitaire des Aliments,
23 avenue du Ge´ne´ral-de-Gaulle, 94706 Maisons-Alfort Cedex, France6; College of Veterinary Medicine, China Agricultural University,
Yuanmingyuan West Road No. 2, Haidian District, Beijing, People’s Republic of China, 1001937; Centre for the Study of
Evolution (CSE), University of Sussex, Brighton BN1 9QL, United Kingdom8; and UCD Schools of Agriculture,
Food Science and Veterinary Medicine,9 Medicine and Medical Science,10 and Biomolecular and
Biomedical Science,11 College of Life Sciences, and UCD Conway Institute of Biomolecular and
Biomedical Research,12 University College Dublin, Dublin 4, Ireland