Surgical hand rub

鬼才

Background: The recommended duration for surgical hand treatment has been changed from 10 over 5 to 3 minutes and even
shorter.
Objectives: Our objective was to study the impact of the length of surgical hand antisepsis with n-propanol 60% (vol/vol) or isopropanol
70% (vol/vol) applied for 1, 3, or 5 minutes on the reduction of resident hand flora in the setting of the microbiologic
laboratory for experimental and applied testing of disinfectants and antiseptics at the Medical University Vienna, Austria, using
a Latin Square design.
Methods: Our methods were according to the Austrian Guidelines for Testing Products for Surgical Hand Antisepsis. The release of
bacterial hand flora of 21 subjects is assessed before and immediately after disinfection from one hand and 3 hours later from the
other, meanwhile gloved, hand. Mean reduction factors (RF) are calculated.
Results: The immediate mean log10 RFs with n-propanol or isopropanol were 1.05, 2.03, and 2.30 and 0.74, 1.48, and 2.12, respectively,
when applied for 1, 3, or 5 minutes, respectively. After 3 hours, the respective mean log10 RFs were 0.45, 1.01, and
1.60 and 0.19, 0.79, and 1.03. Thus, with increasing length of application, a highly significant trend (P , .001) toward higher
log10 reductions was demonstrated. At both sampling times, n-propanol was more effective than isopropanol at the corresponding
treatments. Furthermore, a highly significant (P , .001) association was found between the individual volunteers and the effect of
the antiseptics on their hands.
Conclusion: The efficacy of surgical antisepsis is significantly associated with the length of application.
Copyright ª 2009 by the Association for Professionals in Infection Control and Epidemiology, Inc.
(Am J Infect Control 2009;37:289-93.)
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