新英格兰医学杂志关于1998年台湾肠病毒EV71暴发感染情况的调查汇总（已翻译摘要）

David

N Engl J Med. 1999 Sep 23;341(13):929-35. Links

Comment in:
N Engl J Med. 1999 Sep 23;341(13):984-5.
N Engl J Med. 2000 Feb 3;342(5):355-6.
An epidemic of enterovirus 71 infection in Taiwan.
台湾肠病毒EV71暴发感染情况调查汇总
Taiwan Enterovirus Epidemic Working Group.Ho M, Chen ER, Hsu KH, Twu SJ, Chen KT, Tsai SF, Wang JR, Shih SR.
National Health Research Institutes, Taipei, Taiwan. monto@mail.nhri.org.tw

BACKGROUND: Enteroviruses can cause outbreaks of hand-foot-and-mouth disease (characterized by vesicular lesions on the hands, feet, and oral mucosa) or herpangina, usually without life-threatening manifestations. In 1998 an epidemic of enterovirus 71 infection caused hand-foot-and-mouth disease and herpangina in thousands of people in Taiwan, some of whom died. METHODS: We assessed the epidemiologic aspects of this outbreak. Cases of hand-foot-and-mouth disease or herpangina in ambulatory patients were reported to the Taiwan Department of Health by a mean of 818 sentinel physicians. Severe cases in hospitalized patients were reported by 40 medical centers and regional hospitals. Viruses were isolated by 10 hospital laboratories and the department of health. RESULTS: The sentinel physicians reported 129,106 cases of hand-foot-and-mouth disease or herpangina in two waves of the epidemic, which probably represents less than 10 percent of the estimated total number of cases. There were 405 patients with severe disease, most of whom were five years old or younger; severe disease was seen in all regions of the island. Complications included encephalitis, aseptic meningitis, pulmonary edema or hemorrhage, acute flaccid paralysis, and myocarditis. Seventy-eight patients died, 71 of whom (91 percent) were five years of age or younger. Of the patients who died, 65 (83 percent) had pulmonary edema or pulmonary hemorrhage. Among patients from whom a virus was isolated, enterovirus 71 was present in 48.7 percent of outpatients with uncomplicated hand-foot-and-mouth disease or herpangina, 75 percent of hospitalized patients who survived, and 92 percent of patients who died. CONCLUSIONS: Although several enteroviruses were circulating in Taiwan during the 1998 epidemic, enterovirus 71 infection was associated with most of the serious clinical manifestations and with nearly all the deaths. Most of those who died were young, and the majority died of pulmonary edema and pulmonary hemorrhage.

[ 本帖最后由 David 于 2008-5-3 11:31 编辑 ]

An epidemic of enterovirus 71 infection in Taiwan.pdf (142.06 KB, 下载次数: 23)

2008-4-28 17:36 上传

点击文件名下载附件

David

BACKGROUND: Enteroviruses can cause outbreaks of hand-foot-and-mouth disease (characterized by vesicular lesions on the hands, feet, and oral mucosa) or herpangina, usually without life-threatening manifestations.(背景：肠病毒能够引起手足口病的暴发，典型症状是手、足、口腔粘膜囊泡状病变，或者疱疹性咽峡炎，通常不会危及生命。) In 1998 an epidemic of enterovirus 71 infection caused hand-foot-and-mouth disease and herpangina in thousands of people in Taiwan, some of whom died.（1998年，台湾发生了一次大范围的肠病毒EV71暴发感染，导致数千手足口病和疱疹性咽峡炎的患者，其中一些人死亡。） METHODS: We assessed the epidemiologic aspects of this outbreak. Cases of hand-foot-and-mouth disease or herpangina in ambulatory patients were reported to the Taiwan Department of Health by a mean of 818 sentinel physicians.（方法：我们评估了这次暴发的流行病学影响。急诊病人中手足口病或疱疹性咽峡炎的病例来自台湾卫生部，通过调查818名值班医生得到。） Severe cases in hospitalized patients were reported by 40 medical centers and regional hospitals. （住院患者中的重症病例来自40家医疗中心和地区医院。）Viruses were isolated by 10 hospital laboratories and the department of health. （病毒株分离自10家医院实验室和卫生部的实验室。）RESULTS: The sentinel physicians reported 129,106 cases of hand-foot-and-mouth disease or herpangina in two waves of the epidemic, which probably represents less than 10 percent of the estimated total number of cases.（结果：值班医生报告在两波大流行中共有129106个手足口病或疱疹性咽峡炎病例，可能比估计的总发病数少10%。） There were 405 patients with severe disease, most of whom were five years old or younger; severe disease was seen in all regions of the island. （405例重症患者，大部分为五岁或更小的幼儿，重症患者在全岛范围都有报告。）Complications included encephalitis, aseptic meningitis, pulmonary edema or hemorrhage, acute flaccid paralysis, and myocarditis.（并发症包括脑炎、急性脑膜炎，肺水肿或肺出血，急性驰缓性麻痹和心肌炎。） Seventy-eight patients died, 71 of whom (91 percent) were five years of age or younger. （78人死亡，其中71人占91%为五岁以下幼童。）Of the patients who died, 65 (83 percent) had pulmonary edema or pulmonary hemorrhage.（65人占83%的死亡原因为肺水肿或肺出血。） Among patients from whom a virus was isolated, enterovirus 71 was present in 48.7 percent of outpatients with uncomplicated hand-foot-and-mouth disease or herpangina, 75 percent of hospitalized patients who survived, and 92 percent of patients who died. （48.7%的诊断为单纯手足口病的门诊病人，75%的存活住院患者和92%的死亡患者体内分离出肠病毒EV71病毒株。）CONCLUSIONS: Although several enteroviruses were circulating in Taiwan during the 1998 epidemic, enterovirus 71 infection was associated with most of the serious clinical manifestations and with nearly all the deaths. （结论：尽管在这次1998年台湾暴发中有几种肠病毒流行，但肠病毒EV71感染却与绝大多数重症感染相关，几乎所有死亡病例均检出EV71.）Most of those who died were young, and the majority died of pulmonary edema and pulmonary hemorrhage.(大部分死者为幼童，绝大部分死于肺水肿和肺出血。)

楚楚

每每看到David上传的资料都感动于你的执着奉献精神！谢谢你！你为我们这些英文很差的会员打开了一扇通向世界的大门。:look

临海听涛

下载了，好东东哦。。。