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Clinical Infectious Diseases 2008;46:678–685
MAJOR ARTICLE
Prior Environmental Contamination Increases the Risk of Acquisition of Vancomycin-Resistant Enterococci
Marci Drees,1,2,3 David R. Snydman,1,2,3 Christopher H. Schmid,1,2 Laurie Barefoot,1 Karen Hansjosten,1 Padade M. Vue,3 Michael Cronin,4 Stanley A. Nasraway,1,3 and Yoav Golan1,3
1Tufts–New England Medical Center and 2Sackler School of Graduate Biomedical Sciences and 3School of Medicine, Tufts University, Boston, and 4Tufts University, Medford, Massachusetts
Background. Patients colonized with vancomycin-resistant enterococci (VRE) frequently contaminate their environment, but the environmental role of VRE transmission remains controversial.
Methods. During a 14-month study in 2 intensive care units, weekly environmental and twice-weekly patient surveillance cultures were obtained. VRE acquisition was defined as a positive culture result >48 h after admission. To determine risk factors for VRE acquisition, Cox proportional hazards models using time-dependent covariates for colonization pressure and antibiotic exposure were examined.
Results. Of 1330 intensive care unit admissions, 638 patients were at risk for acquisition, and 50 patients (8%) acquired VRE. Factors associated with VRE acquisition included average colonization pressure (hazard ratio [HR], 1.4 per 10% increase; 95% confidence interval [CI], 1.2–1.8), mean number of antibiotics (HR, 1.7 per additional antibiotic; 95% CI, 1.2–2.5), leukemia (HR, 3.1; 95% CI, 1.2–7.8), a VRE-colonized prior room occupant (HR, 3.1; 95% CI, 1.6–5.8), any VRE-colonized room occupants within the previous 2 weeks (HR, 2.5; 95% CI, 1.3–4.8), and previous positive room culture results (HR, 3.4; 95% CI, 1.2–9.6). In separate multivariable analyses, a VRE-colonized prior room occupant (HR, 3.8; 95% CI, 2.0–7.4), any VRE-colonized room occupants within the previous 2 weeks (HR, 2.7; 95% CI, 1.4–5.3), and previous positive room culture results (HR, 4.4; 95% CI, 1.5–12.8) remained independent predictors of VRE acquisition, adjusted for colonization pressure and antibiotic exposure.
Conclusions. We found that prior room contamination, whether measured via environmental cultures or prior room occupancy by VRE-colonized patients, was highly predictive of VRE acquisition. Increased attention to environmental disinfection is warranted.
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