鲍曼不动杆菌：流行病学，耐药性和治疗建议

David

Clinical Infectious Diseases 2008;46:1254–1263

ANTIMICROBIAL RESISTANCE
INVITED ARTICLE
Acinetobacter baumannii: Epidemiology, Antimicrobial Resistance, and Treatment Options
鲍曼不动杆菌：流行病学，耐药性和治疗建议
Lisa L. Maragakis1,2 and
Trish M. Perl1,2

1Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, and 2Department of Hospital Epidemiology and Infection Control, Johns Hopkins Medical Institutions, Baltimore, Maryland

Multidrug-resistant Acinetobacter baumannii is recognized to be among the most difficult antimicrobial-resistant gram-negative bacilli to control and treat. Increasing antimicrobial resistance among Acinetobacter isolates has been documented, although definitions of multidrug resistance vary in the literature. A. baumannii survives for prolonged periods under a wide range of environmental conditions. The organism causes outbreaks of infection and health care–associated infections, including bacteremia, pneumonia, meningitis, urinary tract infection, and wound infection. Antimicrobial resistance greatly limits the therapeutic options for patients who are infected with this organism, especially if isolates are resistant to the carbapenem class of antimicrobial agents. Because therapeutic options are limited for multidrug-resistant Acinetobacter infection, the development or discovery of new therapies, well-controlled clinical trials of existing antimicrobial regimens and combinations, and greater emphasis on the prevention of health care–associated transmission of multidrug-resistant Acinetobacter infection are essential.

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