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WHO提倡alcohol-based hand rub (ABHR),然而有个潜在的担忧,即可能对医护人员或者患者皮肤有刺激作用。
这是个理论上的推测,考虑到酒精的特性。
酒精为基础的皮肤消毒剂对皮肤真的有伤害吗?
未必如此!
提供一份很有意思的证据!
最新的一项多中心研究(9个sites)表明,传统的肥皂洗手的确可以增加皮肤干燥和过敏发生的可能性【1.02 (1.00-1.03),P = 0.00091】。
理由在于:Frequent handwashing with soap has been shown to gradually deplete superficial lipids and to denature the proteins in the stratum corneum.(使角质层蛋白质变性)
而ABHR不但对皮肤无刺激作用,反而有着强烈的保护效应,降低了皮肤敏感和干燥的可能性【0.98 (0.97-0.99),P =0.0021】(However, staff using an ABHR very frequently (>20 times daily) enjoyed a distinct protective effect.)(可能的原因:the protective effect of ABHRs can be linked to protective additives in the AHBRs )(这一保护效应在单一模型和多因子模型中均证实)
文献出处:Am J Infect Control 2011;39:6-13.)。
Abstract
We performed a prospective multicenter study to assess the dryness and irritation of the hands in health care facilities, and to evaluate whether that disinfection with an alcohol-based hand rub (ABHR) is better tolerated than classic handwashing with mild soap and water. Our study was conducted in 9 sites in the summer and winter. A team of investigators evaluated dryness and irritation(主要观察指标). This study takes into account most of the individual and environmental risk factors (age, sex, use of a protective agent, constitutional factors, personal factors, external factors, institution, function, and number of consecutive working days). The results from the 1932 assessments collected show that traditional handwashing is a risk factor for dryness and irritation, whereas the use of ABHR causes no skin deterioration and might have a protective effect, particularly in intensive use. These results provide a strong argument to counter the rear-guard resistance to the use of ABHRs.
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