治疗鼻部SA携带者可降低手术部位感染——真的有效吗？

wjllulu

(January 6, 2010 - Insidermedicine)

Infections with a type of bacteria known as Staphylococcus aureus, or S. aureus, can be diminished by identifying and treating those who carry it in their nasal passages, according to research published in the New England Journal of Medicine.

Here is some information about hospital-acquired infections:

•    They are a common problem in hospitals worldwide

•    They are a leading cause of death among hospitalized patients

•    They increase the cost of healthcare, primarily by extending the length of hospital stays

Researchers from Erasmus University Medical Center in Rotterdam identified over 900 individuals about to be admitted to hospital who were nasal carriers of S. aureus. The investigators randomized these patients to use an antibiotic nasal ointment and body soap or to a placebo group.

The overall rate of infection was more than twice as high for the patients using a placebo, as compared with those using the antibiotic ointment and soap. The treatment was particularly helpful with respect to preventing deep surgical infections – those who used the placebo were five times more likely to develop such an infection, as compared with those who used the antibiotic therapy. Overall survival rates were similar for both groups of patients.

We spoke with Dr. Henri Verbrugh, MD, PhD, Erasmus University Medical Center, one of the investigators of this study, who offered some further insight.

Today's research suggests that simple procedures for identifying and treating S. aureus in the nose can help reduce the risk of infection among hospitalized patients.

依依

SA携带菌？应该是MRSA携带菌吧。

wjllulu

回复 2# 依依


   文中只是 Staphylococcus aureus,不是Methicillin-resistant Staphylococcus aureus。据说正常人中20%~30%的个体在鼻孔中携带金葡菌。

wjllulu

我提出置疑的依据是，以前看过一篇（国外的）综述说，对鼻孔携带金黄色葡萄球菌且在手术前接受莫匹罗星治疗的患者存在更少的医院内金黄色葡萄球菌感染，与接受安慰剂患者相比是4%对7.7%，p=0.02，但对此做法还是有争议的。而这篇文章说使用安慰剂的那组发生感染可能性5倍于治疗组，真那么有效么？。

xinfeng

应该是MRSA携带菌。。。。。。。。。。

紫色风絮

谢谢老师们的辛勤努力，下载后好好学习。