多重耐药革兰氏阴性菌定植自然史（翻译有奖）

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Natural History of Colonization with Gram‐Negative Multidrug‐Resistant Organisms among Hospitalized Patients
Infect Control Hosp Epidemiol 2010;31:330–337
Objective.To determine the anatomic sites and natural history of colonization with gram-negative multidrug-resistant organisms (MDROs).

Design.Prospective, longitudinal cohort study.

Setting.Walter Reed Army Medical Center, a 236-bed tertiary care center in Washington, DC.

Patients.Deployed subjects (ie, inpatients medically evacuated from Iraq or Afghanistan) or nondeployed subjects admitted to the same hospital.

Methods.Consenting patients had 6 anatomic sites cultured every 3 days for 2 weeks and then weekly. Gram-negative organisms resistant to 3 or more classes of antibiotics were considered MDROs. Isolates were genotyped using pulsed-field gel electrophoresis. Clinical data, data on antibiotic use, and clinical culture results were collected.

Results.Of 60 deployed subjects, 14 (23%) were colonized with an MDRO at admission, and 13 (22%) had incident colonization during hospitalization. The groin was the most sensitive anatomic site for detecting MDRO colonization, and all but one subject remained colonized for the duration of their hospitalization. Sixty percent of subjects with incident Acinetobacter colonization and 25% of subjects with incident Klebsiella colonization had strains that were related to those isolated from other subjects. Of 60 nondeployed subjects, 5 (8%) were colonized with an MDRO at admission; all had recent healthcare contact, and 1 nondeployed subject had an isolate related to a strain recovered from a deployed subject.

Conclusions.Colonization with gram-negative MDROs is common among patients with war-related trauma admitted to a military hospital and also occurs among nondeployed patients with recent healthcare contact. The groin is the most sensitive anatomic site for active surveillance, and spontaneous decolonization is rare.

zhenkai

住院患者中多重耐药革兰氏阴性菌定植的自然史
感染控制流行病学2010; 31:330-337
目的：.决定解剖部位和多重耐药革兰氏阴性菌定植自然史。
设计：纵向队列研究。
设置：Walter Reed陆军医疗中心，一家地处华盛顿的有236个床位的三级医院。
病人：干预对象（即住院病人，是从伊拉克或阿富汗撤离的），对照对象也送往同一医院。
方法：对病人的六个解剖部位每3天采样一次进行2周，然后每周一次。对三种或以上抗生素耐药的革兰氏阴性菌被定义为MDROs.采样凝胶电泳基因分型技术（PFGE）进行基因分型。有关抗生素使用和耐药的临床数据也被同时收集。
结果：在60名干预对象中，有14人（23%）在入院时就检出MRDOs,13人（22％）在住院期间被感染。腹股沟是是检测MDRO最敏感殖的部位，除了一人之外所有人在住院期间均被感染。 60%不动杆菌定植的对象和25%克雷伯菌定植的对象有与其他对象分离出相关联的菌株。在60名对照组中，有5人（8%）在入院时检出1株MRDO。所有对象在近期都有过医疗接触，1名对象分离到的菌株与1名干预对象的分离菌株存在同源性联系。
结论：在部队医院中，多重耐药革兰氏阴性菌定植在战争创伤中是很普遍的，同时也会发生在有医疗接触的对照对象中。腹股沟是动态监测最敏感的部位， 同时自然非定植是很少见的。

zhenkai

翻得不好 见笑
最后一句什么意思啊
spontaneous decolonization is rare
是不是 就是不用药而去除定植是很少见得
理解但是不知道怎么翻

zhenkai

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回复 6# zhenkai
spontaneous decolonization is rare
可不可以翻译成“自发性感染很少见”，请微生物实验室的会员指点一下！