摘大家译:泌尿外科病房院内丙肝感染爆发调查
Clinical course and outcome of a nosocomial outbreak of hepatitis C in a urology ward 泌尿外科病房院内丙肝感染爆发调查
Journal of Hospital Infection
Volume 67, Issue 1, September 2007, Pages 86-91
L.M. Pekovaa, , , P. Teocharovb and A. Sakarevb
aDepartment of Hygiene, Infectious Diseases and Epidemiology, Trakia University, Stara Zagora, Bulgaria
bDepartment of Virology, National Centre of Infectious and Parasitic Diseases, Sofia, Bulgaria
Received 9 January 2007; accepted 8 June 2007. Available online 27 August 2007.
Summary
This paper describes a prospective study of the clinical course and outcome of a nosocomial outbreak of hepatitis C virus (HCV) infection in six male urology patients at a hospital in Stara Zagora, Bulgaria. These patients had been previously hospitalised in the urology ward, during which all had received intravenous therapy. Approximately three weeks later, all six were admitted to the infectious diseases unit with acute hepatitis, shown to be caused by HCV genotype 1b. The diagnosis was confirmed by polymerase chain reaction during the first week of their hospital stay. Infected patients were followed up for 30 months following diagnosis and 54 potential contacts for 6 months post-exposure. Four patients recovered completely; one developed chronic HCV infection and one died. The latter already had cirrhosis due to co-infection with hepatitis B virus. The investigation established the index case as a patient with chronic hepatitis C, who had been an in-patient on the same ward at the same time. The most likely route of transmission was intravenous heparin flushes administered with a common syringe. Contrary to the common assumption that acute HCV infection often leads to chronic disease, only one chronic case was observed during the 30-month period of investigation.
Keywords: Hepatitis C; Nosocomial infection
译文
Clinical course and outcome of a nosocomial outbreak of hepatitis C in a urology ward 泌尿外科病房院内丙肝感染爆发调查
Summary 摘要
This paper describes a prospective study of the clinical course and outcome of a nosocomial outbreak of hepatitis C virus (HCV) infection in six male urology patients at a hospital in Stara Zagora, Bulgaria. 这篇文章报告保加利亚Stara Zagora 一家医院内六个泌尿外科病人发生院内丙肝病毒感染暴发的临床过程和结果。
These patients had been previously hospitalised in the urology ward, during which all had received intravenous therapy. 这些病人先前入住泌尿外科病房,期间都接受静脉内穿刺治疗。
Approximately three weeks later, all six were admitted to the infectious diseases unit with acute hepatitis, shown to be caused by HCV genotype 1b. 将近三周后,所有6个病人均以急性肝炎入住传染科病房,检查显示感染HCVⅠb型。
The diagnosis was confirmed by polymerase chain reaction during the first week of their hospital stay. 这个诊断在入院后的第一周经PCR确诊。
Infected patients were followed up for 30 months following diagnosis and 54 potential contacts for 6 months post-exposure. 对感染的病人进行诊断后追踪随访30个月,并观察暴露后6个月内54种潜在可能的接触。
Four patients recovered completely; one developed chronic HCV infection and one died. The latter already had cirrhosis due to co-infection with hepatitis B virus. 四名患者完全康复,一名发展为慢性丙型肝炎,一名死亡。后者原已存在由于重叠感染HBV引起的肝硬化。
The investigation established the index case as a patient with chronic hepatitis C, who had been an in-patient on the same ward at the same time. 调查发现指示病例是一名慢性乙肝患者,在同一时间住在同一病房。
The most likely route of transmission was intravenous heparin flushes administered with a common syringe. 最可能的传播途径是使用同一付注射器给予静脉内肝素冲管。
Contrary to the common assumption that acute HCV infection often leads to chronic disease, only one chronic case was observed during the 30-month period of investigation. 跟通常假设的急性丙肝会转变为慢性肝炎的情况不同,在30个月的追踪调查中只发现一名患者变成慢性丙肝。
Keywords: Hepatitis C; Nosocomial infection
关键词:丙型肝炎;医院感染
摘要
这篇文章报告保加利亚Stara Zagora 一家医院内六个泌尿外科病人发生院内丙肝病毒感染暴发的临床过程和结果。这些病人先前入住泌尿外科病房,期间都接受静脉内穿刺治疗。将近三周后,所有6个病人均以急性肝炎入住传染科病房,检查显示感染HCVⅠb型。这个诊断在入院后的第一周经PCR确诊。对感染的病人进行诊断后追踪随访30个月,并观察暴露后6个月内54种潜在可能的接触。四名患者完全康复,一名发展为慢性丙型肝炎,一名死亡。后者原已存在由于重叠感染HBV引起的肝硬化。调查发现指示病例是一名慢性乙肝患者,在同一时间住在同一病房。最可能的传播途径是使用同一付注射器给予静脉内肝素冲管。跟通常假设的急性丙肝会转变为慢性肝炎的情况不同,在30个月的追踪调查中只发现一名患者变成慢性丙肝。
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