Microbiology Scientist introduction 2: Qing Deng

细菌耐药

LILY G-231 (Office)
LILY G-201 (Lab)
Biological Sciences
Purdue University
Tel: (765) 494-0423 (Office)
       (765) 496-3237 (Lab)
Fax: (765) 494-0876
qingdeng@purdue.edu

Interests: My interests lie in understanding the basic biology that mediates leukocytes response to infection or injury, and discovery of novel therapeutic agents to suppress detrimental neutrophilic inflammation. Specifically, my research addresses the fundamental questions of what signals are differentially generated during infection and wounding and what intracellular signaling mechanisms guide leukocytes to final destination despite the distractions of other housekeeping chemoattractants. To study these pathways, I utilize zebrafish as a model organism, which not only focused on physiologically relevant signaling events in vivo, but also provides a unique platform for high-resolution in vivo imaging, genetic engineering, gene expression analysis and high-throughput small molecule screens. I also use primary human neutrophils and neutrophil like cells to study migration in vitro to aid biochemical characterization of signaling events.

细菌耐药

Research

My current project involves charactering the role of miRNAs in regulating neutrophil functions. Using next generation sequencing, we have identified miRNAs that are enriched in neutrophils. The immediate goal will be to characterize the contribution of each individual miRNA in regulating neutrophil motility and response to tissue injury or infection using a combination of genetics and imaging tools.

We are also interested in establishing novel infection models using zebrafish where pathogene-host interactions can be made transparent.

细菌耐药

Publications

2016

Zhang Q, Wang D, Jiang G, Liu W, Deng Q, Li X, Qian W, Ouellet H, Sun J.,   (2016) 'EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5.',   Scientific Reports   (In Press)

2015

Jing L, Tamplin OJ, Chen MJ, Deng Q, Patterson S, Kim PG, Durand EM, McNeil A, Green JM, Matsuura S, Ablain J, Brandt MK, Schlaeger TM, Huttenlocher A, Daley GQ, Ravid K, Zon LI.,   (2015) 'Adenosine signaling promotes hematopoietic stem and progenitor cell emergence.',   J Exp Med , 212 ,  5 ,  649-63 PDFView / View**

2014

Knox BP, Deng Q, Rood M, Eickhoff JC, Keller NP, Huttenlocher A.,   (2014) 'Distinct innate immune phagocyte responses to Aspergillus fumigatus conidia and hyphae in zebrafish larvae.',   Eukaryot Cell , 13 ,  10 ,  1266-77 PDFView / View**

2013

Deng Q, Sarris M, Bennin DA, Green JM, Herbomel P, Huttenlocher A.,   (2013) 'Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish.',   J Leuk Biol , 93 ,  5 ,  761-9 PDFView / View**

Berthier E, Lim FY, Deng Q, Guo CJ, Kontoyiannis DK, Wang CC, Beebe DJ, Huttenlocher A, Keller NP.,   (2013) 'Low-volume accessible toolbox for discovering immunosuppressive fungal secondary metabolites. ',   PLos Pathogen , 9 ,  4 ,  e1003289 PDFView / View**

2012

Deng Q, Harvie EA, Huttenlocher A.,   (2012) 'Distinct signaling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury.',   Cell Microbiol , 14 ,  4 ,  517-28 PDFView / View**

2011

Yoo SK, Starnes TW, Deng Q, Huttenlocher A.,   (2011) 'Lyn is a redox sensor that mediates leukocyte wound attraction in vivo.',   Nature , 480 ,  7375 ,  109-12 PDFView / View**

Deng Q, Yoo SK, Cavnar PJ, Green JM, Huttenlocher A.,   (2011) 'Dual Roles for Rac2 in Neutrophil Motility and Active Retention in Zebrafish Hematopoietic Tissue.',   Dev Cell , 21 ,  4 ,  735-45 PDFView / View**

2010

Yoo SK, Deng Q, Cavnar PJ, Wu YI, Hahn KM, Huttenlocher A.,   (2010) 'Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish.',   Dev Cell , 18 ,  2 ,  226-36 PDFView / View**

2008

Deng Q, Barbieri JT.,   (2008) 'Modulation of host cell endocytosis by the type III cytotoxin, Pseudomonas ExoS.',   Traffic , 9 ,  11 ,  1948-57 PDFView / View**

2007

Deng Q, Zhang Y, Barbieri JT.,   (2007) 'Intracellular Trafficking of Pseudomonas ExoS, a Type III Cytotoxin.',   Traffic , 8 ,  10 ,  1331-45 PDFView / View**

Zhang Y, Deng Q, Porath JA, Williams CL, Pederson-Gulrud KJ, Barbieri JT.,   (2007) 'Plasma membrane localization affects the RhoGAP specificity of Pseudomonas ExoS.',   Cell Microbiol , 9 ,  9 ,  2192-201 PDFView / View**

Zhang Y, Deng Q, Barbieri JT.,   (2007) 'Intracellular localization of type III-delivered Pseudomonas ExoS with endosome vesicles.',   J Biol Chem , 282 ,  17 ,  13022-32 PDFView / View**

Peterson FC, Deng Q, Zettl M, Prehoda KE, Lim WA, Way M, Volkman BF.,   (2007) 'Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP.',   J Biol Chem , 282 ,  11 ,  8446-53 PDFView / View**

Maresso AW, Deng Q, Pereckas MS, Wakim BT, Barbieri JT.,   (2007) 'Pseudomonas aeruginosa ExoS ADP-ribosyltransferase inhibits ERM phosphorylation.',   Cell Microbiol , 9 ,  1 ,  97-105 PDFView / View**

2005

Deng Q, Sun J, Barbieri JT.,   (2005) 'Uncoupling Crk signal transduction by Pseudomonas exoenzyme T.',   J Biol Chem , 280 ,  43 ,  35953-60 PDFView / View**

2003

Guo JH, Chen L, Chen S, Liu X, Saiyin H, Deng Q, Zhuang Y, Wan B, Yu L, Zhao SY.,   (2003) 'Isolation, expression pattern of a novel human RAB gene RAB41 and characterization of its intronless homolog RAB41P.',   DNA Seq , 14 ,  6 ,  431-5 PDFView / View**

Review articles

Gurol T, Zhou W, Deng Q. MicroRNAs in neutrophils: potential next generation therapeutics for inflammatory ailments. Immunological reviews (In Press)
Deng Q, Huttenlocher A. Leukocyte migration from a fish eye's view. J Cell Sci.2012 Sep 1;125:3949-56
Deng Q, Barbieri JT. Molecular mechanism of the cytotoxicity of ADP-ribosylating toxins. Annual Review of Microbiology.2008 Oct 13; 62:271-288.
Inivted Presentation

Department of Pharmacology, University of Illinois at Chicago, Chicago, IL (Apr 2013)
19th Annual Midwest Microbial Pathogenesis Conference, Milwaukee, WI, Cxcr2 Mediates Bacteria-Induced Systemic Activation of Neutrophils (Sep 2012)
10th International Conference on Zebrafish Development and Genetics, Madison, WI, Workshop, Models of infection and immunity in zebrafish (Jun 2012)
Conferences Attended

9th Zebrafish Disease Models Conference, Singapore (Oct 2016)
7th Asia Oceania Zebrafish Meeting, Singapore (Oct 2016)
8th Zebrafish Disease Models Conference, Boston, MA (Aug 2015)
21st Annual Midwest Microbial Pathogenesis Conference, Chicago, IL (Sep 2014)
7th Zebrafish Disease Models Conference, Madison, WI (Jun 2014)
19th Annual Midwest Microbial Pathogenesis Conference, Milwaukee, WI (Sep 2012)
Kenneth B. Raper Symposium on Microbial Research, Madison, WI (Aug 2012)
10th International Conference on Zebrafish Development and Genetics, Madison, WI (Jun 2012)
Annual Meeting of The Society for Leukocyte Biology "Infection, Inflammation, Immunity", Kansas City, MO (Sep 2011)
American Society for Cell biology 50th Annual meeting, Philadelphia, PA (Dec 2010)
9th International Conference on Zebrafish Development and Genetics, Madison, WI (Jun 2010)
15th Annual Midwest Microbial pathogenesis Conference, University of Wisconsin, Madison, WI (Sep 2008)
American Society for Microbiology General 107th meeting, Metro Toronto Convention Centre, Toronto, Canada (May 2007)
Virulence Mechanisms of Bacterial Pathogens, International Symposium, Iowa State University, Ames, IA (Sep 2006)
12th Annual Midwest Microbial Pathogenesis Conference, University of Minnesota, Twin Cities, MN (Oct 2005)
Awards

Oral Abstract Award, 19th Annual Midwest Microbial Pathogenesis Conference, 2012
"Novel and news worthy" top pick (10 out of over 1100 abstracts were selected), American Society for Cell biology 50th Annual meeting, 2010
Postdoctoral Travel Award, American Society for Cell Biology, 2010
Graduate Student Travel Award, Medical College of Wisconsin, 2007
Teaching Experience

Instructor, Immunobiolgy (BIOL537, 3 credits), Department of Biological Sciences, Purdue University, 2015
Mentor, the Integrated Biological Sciences Summer Research Program, Institute for Biology Education, University of Wisconsin-Madison, 2011
Affiliations

Sigma Xi, 2011-2012

American Society for Cell Biology, 2010-2011

American Society for Microbiology, 2005-2009

chenqiong

可惜英文基础差，看不懂。要是有翻译就好了。谢谢

明玥

微生物专家邓清的介绍对吗？深深体会书到用时方恨少了

卢旋

明玥 发表于 2017-2-3 07:03
微生物专家邓清的介绍对吗？深深体会书到用时方恨少了

彼此彼此，我也不会，真应该好好学学英文。

tzgengxiuxia

如果以中文发帖，受众会多一些，效果会更好！

星雨落花

只可惜英文的底子太差，文章看不懂，如果能翻译过来就好了。

茉莉香

可惜英文基础差，看不懂。要是有翻译就好了。谢谢

高山雪莲W

美女专家，谢谢版主的分享，可惜只能望文生叹了。

yanziym

介绍微生物专家吗？惭愧，英文交给老师了

云之恋

建议老师少发这类帖子  第一，很多专业性的微生物英语，未从事此类基础性研究的感控人员知之甚少；第二，个人认为我们感控工作者应从宏观层面上认识微生物领域，而不是囫囵吞枣，毕竟我们专业领域不同。

新生命

可惜英文基础差，看不懂。要是有翻译就好了。谢谢

高莉芳y

可惜英文基础差，看不懂。要是有翻译就好了。谢谢

∮滴水藏海∮

看不懂，我的英文是体育老师教的。

wyfywlj

该好好恶补英语了，

衣带渐宽

介绍此专家的目的何在呢？

翔宇

mediates leukocytes response to infection or injury;intracellular signaling mechanisms guide leukocytes to final destination

翔宇

术业有专攻！感谢楼主带来了不一样的精彩！
有时间了解下也是不错的！

yanghongmei

太好了，试图翻译，促进自己学习外语。赞