paper share 3: The Samonella-containing vacuole-Moving with the times

细菌耐药

Before my reseach, my boss give me three paper to learn, I share them with our SIFIC members.

Maybe we can disscussion them, if you are interested in these papers.

This is the third one.

Curr Opin Microbiol. 2008 Feb;11(1):38-45. doi: 10.1016/j.mib.2008.01.002. Epub 2008 Mar 4.
The Salmonella-containing vacuole: moving with the times.Steele-MortimerO
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Abstract

[size=1.04em]Salmonella pathogenesis is dependent on its ability to invade and replicate within host cells. Following invasion the bacteria remain within a modified phagosome known as the Salmonella-containing vacuole (SCV), within which they will survive and replicate. Invasion and SCV biogenesis are dependent on two Type III secretion systems, T3SS1 and T3SS2, which are used to translocate distinct cohorts of bacterial effector proteins into the host cell. Elucidating the roles of individual effector proteins in SCV biogenesis has proven difficult but several distinct themes are now emerging and it is apparent that SCV biogenesis is an extremely dynamic process involving; extensive membrane remodeling, interactions with the endolysosomal pathway, actin rearrangements and microtubule-based movement and tubule extension.

PMID: 18304858