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American Journal of Infection Control
Volume 37, Issue 3, April 2009, Pages 189-194
Major article A prospective survey of air and surface fungal contamination in a medical mycology laboratory at a tertiary care university hospital
一所综合大学医院真菌实验室内空气和物体表面真菌污染的回顾性调查
Marc Sautour PharmD, PhDa, , , Frédéric Dalle PharmD, PhDa, e, Claire Olivieri PharmDa, Coralie L'ollivier PharmDa, e, Emilie Enderlin PharmDa, Elsa Salome MPharma, Isabelle Chovelon PharmDa, Odile Vagner PharmDa, Nathalie Sixt MD, PhDb, Véronique Fricker-Pap MBioa, Serge Aho MDc, Olivier Fontaneau EnvEd, Claire Cachia PharmD, PhDf and Alain Bonnin MD, PhDa, e
aParasitology-Mycology Laboratory, University of Bourgogne, 21079 Dijon Cedex, France
bDepartment of Environmental Microbiology, University of Bourgogne, 21079 Dijon Cedex, France
cDepartment of Hospital Hygiene and Epidemiology, University of Bourgogne, 21079 Dijon Cedex, France
dDepartment of Hospital Engineering, Hôpital du Bocage, University of Bourgogne, 21079 Dijon Cedex, France
eLaboratory Interactions Mucosa-Microorganisms (LIMA, EA 562), University of Bourgogne, 21079 Dijon Cedex, France
fEpidemiology Center of Population (DRED U176), IFR Santé-STIC, Faculty of Medicine and Pharmacy, University of Bourgogne, 21079 Dijon Cedex, France
Available online 6 December 2008.
BackgroundInvasive filamentous fungi infections resulting from inhalation of mold conidia pose a major threat in immunocompromised patients. The diagnosis is based on direct smears, cultural symptoms, and culturing fungi. Airborne conidia present in the laboratory environment may cause contamination of cultures, resulting in false-positive diagnosis. Baseline values of fungal contamination in a clinical mycology laboratory have not been determined to date.
MethodsA 1-year prospective survey of air and surface contamination was conducted in a clinical mycology laboratory during a period when large construction projects were being conducted in the hospital. Air was sampled with a portable air system impactor, and surfaces were sampled with contact Sabouraud agar plates. The collected data allowed the elaboration of Shewhart graphic charts.
ResultsMean fungal loads ranged from 2.27 to 4.36 colony forming units (cfu)/m3 in air and from 0.61 to 1.69 cfu/plate on surfaces.
ConclusionsStrict control procedures may limit the level of fungal contamination in a clinical mycology laboratory even in the context of large construction projects at the hospital site. Our data and the resulting Shewhart graphic charts provide baseline values to use when monitoring for inappropriate variations of the fungal contamination in a mycology laboratory as part of a quality assurance program. This is critical to the appropriate management of the fungal risk in hematology, cancer and transplantation patients.
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发表于 2009-4-4 12:51
