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成功降低碳青霉烯类耐药的肺克传播的感控措施

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发表于 2009-4-4 12:40 | 显示全部楼层 |阅读模式

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Infect Control Hosp Epidemiol 2009;30:447–452 © 2009 by The Society for Healthcare Epidemiology of America. All rights reserved.
0899-823X/2009/3005-0007$15.00
DOI: 10.1086/596734

Original Article
Success of an Infection Control Program to Reduce the Spread of Carbapenem‐Resistant Klebsiella pneumoniae成功降低碳青霉烯类耐药的肺克传播的感控措施Sandeep Kochar, MD;
Timothy Sheard, MA;
Roopali Sharma, PharmD;
Alan Hui, PharmD;
Elaine Tolentino, MS;
George Allen, PhD;
David Landman, MD;
Simona Bratu, MD;
Michael Augenbraun, MD;
John Quale, MD
From the Infectious Diseases Division (S.K., D.L., S.B., M.A., J.Q.), the Infection Control Service (T.S., G.A.), the Pharmacy Service (R.S., A.H.), and the Microbiology Laboratory (E.T.), State University of New York Downstate Medical Center, Brooklyn, New York.
Objective.

                               
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To assess the effect of enhanced infection control measures with screening for gastrointestinal colonization on limiting the spread of carbapenem‐resistant Klebsiella pneumoniae in a New York City hospital endemic for this pathogen.

Design.

                               
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Retrospective observational study with pre‐ and postinterventional phases.

Methods.

                               
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Beginning in 2006, a comprehensive infection control program was instituted in a 10‐bed medical and surgical intensive care unit at a university‐based medical center. In addition to being placed in contact isolation, all patients colonized or infected with carbapenem‐resistant gram‐negative bacilli, vancomycin‐resistant Enterococcus, or methicillin‐resistant Staphylococcus aureus were cohorted to one end of the unit. Improved decontamination of hands and environmental surfaces was encouraged. In addition, routine rectal surveillance cultures were screened for the presence of carbapenem‐resistant pathogens. The number of patients per quarter with clinical cultures positive for carbapenem‐resistant K. pneumoniae was compared during the approximately 2‐year periods before and after the intervention.

Results.

                               
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The mean number (±SD) of new patients per 1,000 patient‐days per quarter with cultures yielding carbapenem‐resistant K. pneumoniae decreased from 9.7 ± 2.2 before the intervention to 3.7 ± 1.6 after the intervention (

                               
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). There was no change in the mean number of patient‐days or the mean number of patients per quarter with cultures yielding methicillin‐resistant Staphylococcus aureus, vancomycin‐resistant Enterococcus, or carbapenem‐resistant Acinetobacter baumannii or Pseudomonas aeruginosa after the intervention. There was no association between antibiotic usage patterns and carbapenem‐resistant K. pneumoniae.

Conclusions.

                               
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The comprehensive intervention that combined intensified infection control measures with routine rectal surveillance cultures was helpful in reducing the incidence of carbapenem‐resistant K. pneumoniae in an intensive care unit where strains producing the carbapenemase KPC were endemic.

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