Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention

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Clin Infect Dis. 2011 Jul 1;53(1):60-7. doi: 10.1093/cid/cir202.

Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention.

[size=0.92em]Gupta N, Limbago BM, Patel JB, Kallen AJ.

Source

Epidemic Intelligence Service, Centers for Disease Control and Prevention, 1600 Clifton Road NE, MS A-35, Atlanta, GA 30333, USA. ngupta1@cdc.gov

Abstract

Over the past 10 years, dissemination of Klebsiella pneumoniae carbapenemase (KPC) has led to an increase in the prevalence of carbapenem-resistant Enterobacteriaceae (CRE) in the United States. Infections caused by CRE have limited treatment options and have been associated with high mortality rates. In the previous year, other carbapenemase subtypes, including New Delhi metallo-β-lactamase, have been identified amongEnterobacteriaceae in the United States. Like KPC, these enzymes are frequently found on mobile genetic elements and have the potential to spread widely. As a result, preventing both CRE transmission and CRE infections have become important public health objectives. This review describes the current epidemiology of CRE in the United States and highlights important prevention strategies.

© The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.