全院范围尿培养筛查产ESBL大肠杆菌和克雷伯菌的效果

江边一碗水

如何控制多重耐药菌感染？筛查后隔离有效吗？这里有一篇最新的（2013年10月出的ICHE刊出）前瞻性半实验研究报告，结果是……

江边一碗水

objective. Optimal strategies for limiting the transmission of extended-spectrum b-lactamase-producing Escherichia coli and Klebsiella spp (ESBL-EK) in the hospital setting remain unclear. The objective of this study was to evaluate the impact of a urine culture screening strategy on the incidence of ESBL-EK.
design. Prospective quasi-experimental study.
setting. Two intervention hospitals and one control hospital within a university health system from 2005 to 2009.
patients and intervention. All clinical urine cultures with E. coli or Klebsiella spp were screened for ESBL-EK. Patients determined
to be colonized or infected with ESBL-EK were placed in a private room with contact precautions. The primary outcome of interest was nosocomial ESBL-EK incidence in nonurinary clinical cultures (cases occurring more than 48 hours after admission). Changes in monthly ESBL-EK incidence rates were evaluated with mixed-effects Poisson regression models, with adjustment for institution-level characteristics (eg, total admissions).
results. The overall incidence of ESBL-EK increased from 1.42/10,000 patient-days to 2.16/10,000 patient-days during the study period. The incidence of community-acquired ESBL-EK increased nearly 3-fold, from 0.33/10,000 patient-days to 0.92/10,000 patient-days (P !). On multivariable analysis, the intervention .001 was not significantly associated with a reduction in nosocomial ESBL-EK incidence (incidence rate ratio, 1.38 [95% confidence interval, 0.83–2.31]; Pp.21).
conclusions. Universal screening of clinical urine cultures for ESBL-EK did not result in a reduction in nosocomial ESBL-EK incidence rates, most likely because of increases in importation of ESBL-EK cases from the community. Further studies are needed on elucidating optimal infection control interventions to limit spread of ESBL-producing organisms in the hospital setting.


Infect Control Hosp Epidemiol 2013;34(11):1160-1166

月光下的白狐

水平有限，能不能有中文版的？

刘鹏

学习了

lunna26

江边一碗水 发表于 2013-10-28 15:30
objective. Optimal strategies for limiting the transmission of extended-spectrum b-lactamase-produci ...

江边老师，这个是说社区增加3倍，医院感染通过一系列措施有减少，但是RR是1.38，在95%的可信区间内，所以没有显著意义吗？