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The Journal of Antibiotics (2012) 65, 385–395
& 2012 Japan Antibiotics Research Association All rights reserved 0021-8820/12
Thoughts and facts about antibiotics: Where we are
now and where we are heading
This article has been corrected since advance Online Publication, and a corrigendum is also printed in this issue.
Ja´nos Be´rdy
The declining trends in microbial metabolite and natural products research and the refocusing of this research area are
discussed. Renewing natural products research requires inexhaustible natural resources, as well as new genetic techniques and
microbial sources, including endophytic microbes. The numbers of known bioactive metabolites are summarized according to
their microbiological origin, biological activities and chemical structures. Synthetic and natural product-based libraries are also
compared. Importantly, the wide range of microbial metabolite bioactivities, future trends and the importance of prioritizing
natural products over synthetic compounds are emphasized.
The Journal of Antibiotics (2012) 65, 385–395; doi:10.1038/ja.2012.27; published online 18 April 2012
Keywords: antibiotics; bioactive microbial metabolites; biodiversity; future prospects; non-antibiotic bioactivities; taxonomic diversity
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发表于 2012-8-31 11:58
关于抗生素的现状和思考：我们现在在哪？我们正向哪儿前行？