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Background: Previous reviews of the effectiveness of antibiotic prophylaxis for elect -
ive inguinal hernia repair were not conclusive owing to the limited number of patients
enrolled in randomized controlled trials (RCTs). However, since new RCTs involving
patients undergoing tention-free hernioplasty have been published in recent years, we
performed a new meta-analysis to evaluate the effectiveness of antibiotic prophylaxis
in the prevention of postoperative complications after this procedure.
Methods:We performed a meta-analysis of RCTs studying the use of antibiotic prophylaxis
to prevent postoperative complications in patients undergoing tension-free
hernioplasty.
Results:We included 6 RCTs conducted around the world in our analysis. Compared
with the control condition, antibiotic prophylaxis was associated with a lower incidence
of incision infection (odds ratio [OR] 0.45, 95% confidence interval [CI] 0.26–
0.77, p = 0.004). There were no significant differences in risk for incision hematoma
(OR 1.57, 95% CI 0.60–4.10, p = 0.35), respiratory infection (OR 1.00, 95% CI 0.17–
5.79, p > 0.99) or urinary tract infection (OR 1.81, 95% CI 0.38–8.52, p = 0.45)
between the 2 conditions.
Conclusion: Antibiotic prophylaxis use in patients undergoing tension-free hernioplasty
decreases the rate of incision infection by 55%.
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发表于 2012-7-29 20:33