鲍曼不动杆菌：成功的致病菌（CMR巨作）

David

Clinical Microbiology Reviews, July 2008, p. 538-582, Vol. 21, No. 3

Acinetobacter baumannii: Emergence of a Successful Pathogen
鲍曼不动杆菌：成功的致病菌
Anton Y. Peleg,1* Harald Seifert,2 and David L. Paterson3,4,5
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts,1 Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19-21, 50935 Cologne, Germany,2 University of Queensland, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia,3 Pathology Queensland, Brisbane, Queensland, Australia,4 Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania5

Acinetobacter baumannii has emerged as a highly troublesome pathogen for many institutions globally. As a consequence of its immense ability to acquire or upregulate antibiotic drug resistance determinants, it has justifiably been propelled to the forefront of scientific attention. Apart from its predilection for the seriously ill within intensive care units, A. baumannii has more recently caused a range of infectious syndromes in military personnel injured in the Iraq and Afghanistan conflicts. This review details the significant advances that have been made in our understanding of this remarkable organism over the last 10 years, including current taxonomy and species identification, issues with susceptibility testing, mechanisms of antibiotic resistance, global epidemiology, clinical impact of infection, host-pathogen interactions, and infection control and therapeutic considerations.



--------------------------------------------------------------------------------
* Corresponding author. Mailing address: Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis Street, LMOB Suite GB, Boston, MA 02215. Phone: (617) 667-7000. Fax: (617) 632-7626. E-mail: apeleg@bidmc.harvard.edu