控制及预防艰难梭菌感染的方法

David

Clinical Infectious Diseases 2008;46:S43–S49


SUPPLEMENT ARTICLE
Measures to Control and Prevent Clostridium difficile Infection
控制及预防艰难梭菌感染的方法
Dale N. Gerding,1,2
Carlene A. Muto,3 and
Robert C. Owens, Jr.4,5

1Hines Veterans Affairs Hospital, Hines, and 2Loyola University Chicago Stritch School of Medicine, Chicago, Illinois; 3University of Pittsburgh Medical Center–Presbyterian Campus, Pittsburgh, Pennsylvania; 4Maine Medical Center, Portland; and 5University of Vermont College of Medicine, Burlington

Reprints or correspondence: Dr. Dale N. Gerding, Hines Veterans Affairs Hospital, 5th Ave. & Roosevelt Rd., P.O. Box 5000, Hines, IL 60141 (dale.gerding2@va.gov).
Control of Clostridium difficile infection (CDI) outbreaks in health care facilities presents significant challenges to infection control specialists and other health care workers. C. difficile spores survive routine environmental cleaning with detergents and hand hygiene with alcohol-based gels. Enhanced cleaning of all potentially contaminated surfaces with 10% sodium hypochlorite reduces the environmental burden of C. difficile, and use of barrier precautions reduces C. difficile transmission. Thorough handwashing with chlorhexidine or with soap and water has been shown to be effective in removing C. difficile spores from hands. Achieving high-level compliance with these measures is a major challenge for infection control programs. Good antimicrobial stewardship complements infection control efforts and environmental interventions to provide a comprehensive strategy to prevent and control outbreaks of CDI. The efficacy of metronidazole or vancomycin prophylaxis to prevent CDI in patients who are receiving other antimicrobials is unproven, and treatment with these agents is ineffective against C. difficile in asymptomatic carriers.

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