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J Hosp Infect. 2007 Sep 18;
Outbreak of surgical infection caused by non-tuberculous mycobacteria in breast implants in Brazil. 在巴西因隆胸引起的非结核分支杆菌感染爆发
Padoveze MC, Fortaleza CM, Freire MP, Brandão de Assis D, Madalosso G, Pellini AC, César ML, Pisani Neto V, Beltramelli MM, Chimara E, Ferrazoli L, da Silva Telles MA, Sampaio JL, Leão SC.
Centro de Vigilância Epidemiológica ‘Prof. Alexandre Vranjac’, State Health Department, Hospital Infection Division, São Paulo, Brazil.
SUMMARY: We investigated an outbreak caused by non-tuberculous mycobacteria (NTM) related to breast implant surgery in the city of Campinas, Brazil, by means of a retrospective cohort and molecular epidemiological study.我们在巴西坎皮纳斯市调查一起因乳房假体植入手术而引起的非结核分支杆菌感染爆发事件，同时开展回顾性队列研究和分子流行病学研究。 A total of 492 records of having breast surgery in 12 hospitals were evaluated. 对12家医院有进行过隆胸手术的492人进行调查。Twelve isolates were analysed using four different molecular typing methods. 12株菌株用4种不同的分子生物学方法进行分析。There were 14 confirmed cases, 14 possible cases and one probable case. 最后确诊14例，疑似病例14例 ，可能病例1例。One probable, nine possible and 12 confirmed cases were included in a cohort study; all occurred in eight of the hospitals and the confirmed cases in five.1例可能病例，9例疑似病例和12例确诊病例进入队列研究；这些病例来自8个医院，其中确诊病例来自5个医院。 Univariate analysis showed that patients who had had breast reconstruction surgery in hospitals A and B were more likely to have NTM infections.单变量分析显示在A和B医院做过乳房手术的病人更容易感染非结核分支杆菌。 No risk factor was independently associated with NTM infection in the multivariate model.多因素分析中没有发现与非结核分支杆菌感染的独立危险因素。 The isolates obtained from patients at each hospital showed different molecular patterns, excluding isolates from hospital C that repeatedly showed the same genotype for approximately one year.除了C医院在大约一年中分离出同样的基因型外，在其他医院分离出的菌株显示出不同的基因型。 In conclusion, this outbreak was caused by polyclonal strains at different institutions, and in one hospital a unique genotype caused most cases. No specific risk factors were found.结论，这是一起在不同医疗机构因非结核分支杆菌克隆株引起的爆发，一个医院都有不同的基因型。没有发现特殊的感染危险因素。 |
发表于 2007-11-8 10:48
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