文摘大家译：短时0.05%洗必泰消毒不会影响人类非关节炎软骨代谢

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Brief exposure of 0.05% chlorhexidine does not impair non-osteoarthritic human cartilage metabolism Journal of Hospital Infection 短时0.05%洗必泰消毒不会影响人类非关节炎软骨代谢
Volume 67, Issue 1, September 2007, Pages 67-71
A.J. Besta, M.F. Nixon , a,  and G.J.S. Taylora
aDepartment of Orthopaedic Surgery, Glenfield Hospital, Leicester, UK
Received 8 September 2006;  accepted 11 May 2007.  Available online 30 July 2007.


Summary
Jet lavage with chlorhexidine 0.05% is an effective means of wound decontamination with 99% of bacteria removed or killed after 1 min. Reports of chondrolysis following exposure to concentrations of >0.05% or prolonged exposure to chlorhexidine have curtailed its use in orthopaedic practice. Using radiolabelled sulphur uptake to measure cartilage metabolism, we quantitatively assessed the in-vitro effect of osteoarthritic and non-osteoarthritic human cartilage exposure to chlorhexidine 0.05% for 1 min and 1 h. The metabolism of non-osteoarthritic cartilage was not significantly affected by a 1 min exposure to chlorhexidine 0.05% whereas that of osteoarthritic cartilage was markedly impaired. Prolonged exposure for 1 h markedly affected both types of cartilage. These results are encouraging in that 0.05% chlorhexidine may have a role in the decontamination of contaminated open joint injuries in patients with no signs of osteoarthritis. Until there is further understanding of the mechanism underlying reported incidents of chondrolysis following its use, however, it cannot be recommended for the irrigation of ‘clean’ articular cartilage.
Keywords: Wound infection; Cartilage; Chlorhexidine; Osteoarthritis

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Jet lavage with chlorhexidine 0.05% is an effective means of wound decontamination with 99% of bacteria removed or killed after 1 min. 用0.05%洗必泰灌洗是伤口去污染的有效方法，作用1分钟可去除或杀灭99%细菌。 Reports of chondrolysis following exposure to concentrations of >0.05% or prolonged exposure to chlorhexidine have curtailed its use in orthopaedic practice.使用浓度大于0.05%洗必泰或长时间接触导致软骨溶解的报道已经使它在骨科中的应用减少。 Using radiolabelled sulphur uptake to measure cartilage metabolism, we quantitatively assessed the in-vitro effect of osteoarthritic and non-osteoarthritic human cartilage exposure to chlorhexidine 0.05% for 1 min and 1 h. 使用放射性标记硫摄取测量软骨代谢，我们定量评估接触0.05%洗必泰1分钟和1小时后对骨关节炎与非骨关节炎人软骨的影响。The metabolism of non-osteoarthritic cartilage was not significantly affected by a 1 min exposure to chlorhexidine 0.05% whereas that of osteoarthritic cartilage was markedly impaired. 非骨关节炎软骨代谢在其接触0.05%洗必泰1分钟后没有受到严重影响，反之，骨关节炎软骨代谢则受到显著损害。
Prolonged exposure for 1 h markedly affected both types of cartilage. 延长接触时间达1小时可明显影响两种软骨代谢。These results are encouraging in that 0.05% chlorhexidine may have a role in the decontamination of contaminated open joint injuries in patients with no signs of osteoarthritis. 这些结果提示对于没有骨关节炎体征的病人，0.05%洗必泰对污染开放性关节损伤的去污染起作用。Until there is further understanding of the mechanism underlying reported incidents of chondrolysis following its use, however, it cannot be recommended for the irrigation of ‘clean’ articular cartilage. 然而在原来报告的洗必泰对代谢影响的事件没有得到更进一步的理解之前，不能推荐用于清洁关节软骨的灌洗。
Keywords: Wound infection; Cartilage; Chlorhexidine; Osteoarthritis
关键词：伤口感染；软骨；洗必泰；骨关节炎
用0.05%洗必泰灌洗是伤口去污染的有效方法，作用1分钟可去除或杀灭99%细菌。使用浓度大于0.05%洗必泰或长时间接触导致软骨溶解的报道已经使它在骨科中的应用减少。使用放射性标记硫摄取测量软骨代谢，我们定量评估接触0.05%洗必泰1分钟和1小时后对骨关节炎与非骨关节炎人软骨的影响。非骨关节炎软骨代谢在其接触0.05%洗必泰1分钟后没有受到严重影响，反之，骨关节炎软骨代谢则受到显著损害。延长接触时间达1小时可明显影响两种软骨代谢。这些结果提示对于没有骨关节炎体征的病人，0.05%洗必泰对污染开放性关节损伤的去污染起作用。然而在原来报告的洗必泰对代谢影响的事件没有得到更进一步的理解之前，不能推荐用于清洁关节软骨的灌洗。
关键词：伤口感染；软骨；洗必泰；骨关节炎

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