Nationwide Study of Humidifier Disinfectant Lung Injury in South Korea, 1994-...

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Nationwide Study of Humidifier Disinfectant Lung Injury in South Korea, 1994-2011. Incidence and Dose-Response Relationships.看到葛主任的帖子，把这篇原文八出来给大家学习！
Paek D1, Koh Y2, Park DU3, Cheong HK4, Do KH2, Lim CM2, Hong SJ2, Kim YH5, Leem JH6, Chung KH7, Choi YY8, Lee JH9, Lim SY10, Chung EH11, Cho YA2, Chae EJ2, Joh JS11, Yoon Y11, Lee KH12, Choi BY13, Gwack J14.
Author information

• 11 School of Public Health, Seoul National University, Seoul, Korea.
• 22 Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
• 33 Korea National Open University, Seoul, Korea.
• 44 School of Medicine and.
• 55 Korea Institute of Toxicology, Daejeon, Korea.
• 66 Inha University Hospital, Incheon, Korea.
• 77 School of Pharmacy, Sungkyunkwan University, Suwon, Korea.
• 88 Asian Citizen's Center for Environment and Health, Seoul, Korea.
• 99 Institute of Environmental Safety and Protection, NeoEnBiz Company, Bucheon, Korea.
• 1010 College of Medicine, Kyung Hee University, Seoul, Korea.
• 1111 National Medical Center, Seoul, Korea.
• 1212 Korea Institute of Toxicology, Jeongup, Korea.
• 1313 College of Medicine, Hanyang University, Seoul, Korea; and.
• 1414 Korea Centers for Disease Control and Prevention, Cheongju, Korea.
  

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Abstract
RATIONALE: Humidifier disinfectant lung injury is an acute lung disease attributed to recurrent inhalation of certain disinfectant aerosols emitted from room humidifiers. An outbreak of this toxic lung injury occurred in South Korea from 1995 until all humidifier disinfectant products were recalled from the consumer market by the government in 2011.
OBJECTIVES: A nationwide study was conducted to ascertain and classify all potential cases of humidifier disinfectant lung injury in Korea and to assess dose-response relationships.
METHODS: By several mechanisms, clinicians and the general public were invited to report all suspected cases of humidifier disinfectant lung injury to public health officials in South Korea. A committee was convened to define diagnostic criteria based on pathologic, radiologic, and clinical findings for index cases, combined with assessment of environmental exposure to humidifier disinfectants. Clinical review and environmental assessments were performed and later combined to determine overall likelihood of disease for each study participant, classified as definite, probable, possible, or unlikely. Survival time from exposure to onset of symptoms was analyzed to assess dose-response relationships. Three broad categories of risk factors were examined: (1) biological susceptibility, (2) temporal cycle of exposure and recovery, and (3) spatial conditions and density of disinfectant.
MEASUREMENTS AND MAIN RESULTS: Of 374 possible cases identified and reviewed, 329 were unanimously classified by the diagnostic committee, as follows: 117 definite, 34 probable, 38 possible and 140 unlikely cases. A total of 62 individuals with definite or probable disease died. Risk factors examined for polyhexamethyleneguanidine phosphate exposure that were found to be significant in shortening survival included age 4 years or younger at onset, use of disinfectant for 7 days per week, airborne density of 800 μg/m(3) or more of disinfectant, and daily exposure 11 or more hours in duration.
CONCLUSIONS: Dose-response analysis indicated that development of humidifier disinfectant lung injury and death were associated strongly with recurrent, intense, acute exposure without sufficient recovery time between exposures, more so than long-term cumulative exposure. These findings may explain some reversible or clinically unapparent cases among coexposed family members.
KEYWORDS: humidifier biocide; methylisothiazolinone; minimum acute exposure; oligo(2-(2-ethoxy)ethoxyethylguanidinium chloride; polyhexamethyleneguanidine phosphate

LZQ001

不能完全看懂，有待学习提高！！

toto

LZQ001 发表于 2016-5-27 11:41
不能完全看懂，有待学习提高！！

可以借助翻译软件，基本内容看懂应该是没有问题的！

LZQ001

谢谢老师，520！祝您再创辉煌！！

hyefen

不能完全看懂，有待学习提高！！

鬼才

呵呵，只是上传了一个文献摘要，最好把原文的PDF文件上传，谢谢了。