全球出现新怪病类似艾滋 台湾50多人感染
期：2012-08-24来源：中国新闻网据报道，此症患者与艾滋病毒感染者一样、免疫力比常人差，常因感染就医，例如住在美国的越南裔女子阮金，3年前因发烧等感染疾病就医，多年来病情时好时坏。
据台湾《苹果日报》报道，医界发现近年在台湾地区、泰国及美国等地出现一种新怪病，病患没感染艾滋病、但却出现类似艾滋病的免疫力极度低下症状，全球确诊200多例，台湾患者50多人。因患者至今全为亚裔黄种人，因此被命名为“亚洲新型免疫缺损症”。医师说，此病好发于50岁，致病原因不明，但确定不会人传人。
国际医学权威期刊《新英格兰医学期刊》昨刊载由台湾地区、泰国及美国等医学研究人员合力的研究，确认全球出现一种新病症。参与研究的台湾成功大学临床医学研究所所长兼儿科教授谢奇璋昨(23日)表示，一般免疫疾病患者是免疫系统产生抗体攻击身体各部分，但新病症患者出现“免疫力暴冲”现象，会产生特别的抗体，攻击免疫系统，导致免疫力下降。
谢奇璋表示，研究共收集200多名患者，台湾地区有50多人，他们都曾发生严重霉菌、分枝杆菌或沙门氏菌等特定细菌感染，“有人霉菌长得全身都是，有人罹患分枝杆菌肺炎，怎样治都治不了”，经免疫检查，确诊是罹患亚洲新型免疫缺损症，所幸台湾病例都没死亡。
谢奇璋说，目前发现罹病者都是亚裔黄种人，发病年龄约50岁，与遗传无关，不会传染，患者平日无异常，但当感染上述几种细菌时，“病情远比一般人严重，没控制好，可能死亡”。
据报道，此症患者与艾滋病毒感染者一样、免疫力比常人差，常因感染就医，例如住在美国的越南裔女子阮金，3年前因发烧等感染疾病就医，多年来病情时好时坏。
马偕医院皮肤科主治医师孙培伦则表示，一般霉菌感染经用药1个月可康复，但若是霉菌蔓延到脸部、躯干、四肢都有，或常感染且久治不愈，可能是免疫力出问题，建议最好到大医院检查。
“亚洲新型免疫缺损症”小档案
病因：患者体内产生一种会攻击、吞噬白血球免疫细胞激素的特殊抗体，导致免疫力下降，难以抵挡霉菌、分枝杆菌、沙门氏菌等特定细菌感染
症状：平时无异状，但感染上述特定细菌时，病情会比一般人严重，甚至死亡好
发族群：年约50岁的亚裔黄种人，台湾确诊病例数约50多人
特性：不会人传人，也无遗传倾向
治疗：免疫疗法，但疗效尚未获证实
我们还没有搞清楚艾滋，又来个损害免疫力的！麻烦！ 这世界究竟是怎么了，如此新怪病侵袭人类，太可怕了 确实非常恐怖！
找了一下，应该是这篇文章吧：
Adult-Onset Immunodeficiency in Thailand and Taiwan
Sarah K. Browne, M.D., Peter D. Burbelo, Ph.D., Ploenchan Chetchotisakd, M.D., Yupin Suputtamongkol, M.D., Sasisopin Kiertiburanakul, M.D., Pamela A. Shaw, Ph.D., Jennifer L. Kirk, B.A., Kamonwan Jutivorakool, M.D., Rifat Zaman, B.S., Li Ding, M.D., Amy P. Hsu, B.A., Smita Y. Patel, M.D., Kenneth N. Olivier, M.D., Viraphong Lulitanond, Ph.D., Piroon Mootsikapun, M.D., Siriluck Anunnatsiri, M.D., Nasikarn Angkasekwinai, M.D., Boonmee Sathapatayavongs, M.D., Po-Ren Hsueh, M.D., Chi-Chang Shieh, M.D., Ph.D., Margaret R. Brown, B.S., Wanna Thongnoppakhun, Ph.D., Reginald Claypool, R.N., Elizabeth P. Sampaio, M.D., Ph.D., Charin Thepthai, M.Sc., Duangdao Waywa, M.Sc., Camilla Dacombe, R.N., Yona Reizes, R.N., Adrian M. Zelazny, Ph.D., Paul Saleeb, M.D., Lindsey B. Rosen, B.S., Allen Mo, B.S., Michael Iadarola, Ph.D., and Steven M. Holland, M.D.
N Engl J Med 2012; 367:725-734August 23, 2012
BACKGROUND
Autoantibodies against interferon-γ are associated with severe disseminated opportunistic infection, but their importance and prevalence are unknown.
METHODS
We enrolled 203 persons from sites in Thailand and Taiwan in five groups: 52 patients with disseminated, rapidly or slowly growing, nontuberculous mycobacterial infection (group 1); 45 patients with another opportunistic infection, with or without nontuberculous mycobacterial infection (group 2); 9 patients with disseminated tuberculosis (group 3); 49 patients with pulmonary tuberculosis (group 4); and 48 healthy controls (group 5). Clinical histories were recorded, and blood specimens were obtained.
RESULTS
Patients in groups 1 and 2 had CD4+ T-lymphocyte counts that were similar to those in patients in groups 4 and 5, and they were not infected with the human immunodeficiency virus (HIV). Washed cells obtained from patients in groups 1 and 2 had intact cytokine production and a response to cytokine stimulation. In contrast, plasma obtained from these patients inhibited the activity of interferon-γ in normal cells. High-titer anti–interferon-γ autoantibodies were detected in 81% of patients in group 1, 96% of patients in group 2, 11% of patients in group 3, 2% of patients in group 4, and 2% of controls (group 5). Forty other anticytokine autoantibodies were assayed. One patient with cryptococcal meningitis had autoantibodies only against granulocyte–macrophage colony-stimulating factor. No other anticytokine autoantibodies or genetic defects correlated with infections. There was no familial clustering.
CONCLUSIONS
Neutralizing anti–interferon-γ autoantibodies were detected in 88% of Asian adults with multiple opportunistic infections and were associated with an adult-onset immunodeficiency akin to that of advanced HIV infection. (Funded by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research; ClinicalTrials.gov number, NCT00814827.) 太可怕了啊，专家们快支招，怎么防控啊？
按HBV、HCV、HIV的排序，这又排到HXV呢？恐怖啊！ 佳蕙淼淼 发表于 2012-8-25 10:51 static/image/common/back.gif
我们还没有搞清楚艾滋，又来个损害免疫力的！麻烦！
在国内也有类艾滋病患者，据调查都有不良的性取向。不知台湾发现的这些人群有没有什么共同特点。 良好的卫生习惯，健康的生活方式很重要嘞！{:1_13:} 恐怖归恐怖，有时候也得要以“不变应万变”，谁都难以预料下一刻会出现哪一种更难应对的疾病。 好在不会传染，要不然又麻烦了。我想问下经血液也不会传播吗
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