Antibody-based protection against HIV infection by vectored immunoprophylaxis
espite tremendous efforts, development of an effective vaccine against human immunodeficiency virus (HIV) has proved an elusive goal. Recently, however, numerous antibodies have been identified that are capable of neutralizing most circulating HIV strains1, 2, 3, 4, 5. These antibodies all exhibit an unusually high level of somatic mutation6, presumably owing to extensive affinity maturation over the course of continuous exposure to an evolving antigen7. Although substantial effort has focused on the design of immunogens capable of eliciting antibodies de novo that would target similar epitopes8, 9, 10, it remains uncertain whether a conventional vaccine will be able to elicit analogues of the existing broadly neutralizing antibodies. As an alternative to immunization, vector-mediated gene transfer could be used to engineer secretion of the existing broadly neutralizing antibodies into the circulation. Here we describe a practical implementation of this approach, which we call vectored immunoprophylaxis (VIP), which in mice induces lifelong expression of these monoclonal antibodies at high concentrations from a single intramuscular injection. This is achieved using a specialized adeno-associated virus vector optimized for the production of full-length antibody from muscle tissue. We show that humanized mice receiving VIP appear to be fully protected from HIV infection, even when challenged intravenously with very high doses of replication-competent virus. Our results suggest that successful translation of this approach to humans may produce effective prophylaxis against HIV.【突破：成功实现对艾滋病的终身免疫】Nature：加州科学家利用基于基因疗法的新型接种免疫VIP方法，只需注射一次，就让小鼠获得艾疾病的终身全面免疫。就算向小鼠静脉滴注高浓度病毒也不能使其感染。该方法利用改良腺病毒为载体，其插入了HIV中和抗体的DNA，然后注射到肌肉
012年的诺贝尔医学奖的得主！！！
是人类的重大突破，可喜可贺。
天还在为艾滋病病毒感染的小朋友揪心，今天就看到了这样的好消息，希望早日有疫苗应用于临床。
望早日进入临床试验！给病人带来真正福音！
只是实验阶段，成功的应用于人类或临床还有很长的路要走，期待！
个消息给人类预防HIV感染带来希望！
主老师的这个信息不仅仅让我们广大医务人员着实松了一口气，也让广大的患者有了某种期盼感，真诚的希望该疫苗能早日问世，为全人类带来福音！
望在远方，但毕竟有。与院感有关呀。。。谢谢
谢男丁格尔老师提供的信息，读后感觉有点儿像自己的名字“彩虹在心中”的寓意，心中有很多美好的愿望，尽管现实难以达到，总还是充满希望。{:1_1:}
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