中国科学家发现禽流感病毒可母婴传播
中国科学家发现禽流感病毒可母婴传播2007-10-25 16:30:44 来源: 新华社(北京)
核心提示：我国科学家经过研究发现，感染禽流感病毒的孕妇可以将病毒传染给胎儿。孕妇感染胎儿证明病毒不是从呼吸道而是从血液中进入的，说明病毒除呼吸道外还有其他传播途径。
新华网北京１０月２５日电 我国科学家经过研究发现，感染禽流感病毒的孕妇可以将病毒传染给胎儿。
北京大学基础医学院院长、病理学系主任顾江教授领导的课题组对２例因禽流感死亡的尸体，进行了近２年的试验研究。他们发现，禽流感病毒除感染肺脏之外还侵袭人的气管、消化道（肠道）、大脑里的神经元等多器官细胞。这一发现推翻了以往禽流感病毒只存在于肺部的论断。
令人关注的另一个重点是，课题组得到的２例尸体中，一个是２４岁的孕妇。课题组发现孕妇的胎盘中存在病毒，胎儿的肺中也有病毒。这说明病毒可以穿过胎盘屏障传染给胎儿，而一般的人流感病毒是不会穿过胎盘的。孕妇感染胎儿证明病毒不是从呼吸道而是从血液中进入的，说明病毒除呼吸道外还有其他传播途径。
医学界此前的相关研究还没有找到禽流感由人传染人的确凿证据，因此有禽流感病毒不能人传人的论断。
顾江教授说，胎儿虽然还不是通常意义上的人，在母亲体内是胎儿，生下来则是一个与母亲基因和表现型都不同的人。病毒有传染胎儿的能力，就很可能有传染新生儿的能力，有传染儿童的能力和成人的能力。出生后的人有更强的抵抗力，受体也可能有些变化，且与带病毒者的接触密切程度和接触的病毒量都有所减低，但传播原理是相通的。 (本文来源：新华网 作者：李江涛)
[ 本帖最后由 一枝梅 于 2007-10-26 12:59 编辑 ]
回复 #1 一枝梅 的帖子
一个不好的消息！:( :( 冬季降临，我们又要开始忙着防控禽流感了。总有一天，我们会大忙一场的。
回复 #1 一枝梅 的帖子
找到了英文论文摘要，供大家参考。虽然只有两例，确实是重大发现。H5N1 infection of the respiratory tract and beyond: a molecular pathology study.Gu J, Xie Z, Gao Z, Liu J, Korteweg C, Ye J, Lau LT, Lu J, Gao Z, Zhang B, McNutt MA, Lu M, Anderson VM, Gong E, Yu AC, Lipkin WI. Lancet. 2007 Sep 29;370(9593):1137-45
Infectious Disease Centre, Peking University, Beijing, China. jianggu@bjmu.edu.cn
BACKGROUND: Human infection with avian influenza H5N1 is an emerging infectious disease characterised by respiratory symptoms and a high fatality rate. Previous studies have shown that the human infection with avian influenza H5N1 could also target organs apart from the lungs. METHODS: We studied post-mortem tissues of two adults (one man and one pregnant woman) infected with H5N1 influenza virus, and a fetus carried by the woman. In-situ hybridisation (with sense and antisense probes to haemagglutinin and nucleoprotein) and immunohistochemistry (with monoclonal antibodies to haemagglutinin and nucleoprotein) were done on selected tissues. Reverse-transcriptase (RT) PCR, real-time RT-PCR, strand-specific RT-PCR, and nucleic acid sequence-based amplification (NASBA) detection assays were also undertaken to detect viral RNA in organ tissue samples. FINDINGS: We detected viral genomic sequences and antigens in type II epithelial cells of the lungs, ciliated and non-ciliated epithelial cells of the trachea, T cells of the lymph node, neurons of the brain, and Hofbauer cells and cytotrophoblasts of the placenta. Viral genomic sequences (but no viral antigens) were detected in the intestinal mucosa. In the fetus, we found viral sequences and antigens in the lungs, circulating mononuclear cells, and macrophages of the liver. The presence of viral sequences in the organs and the fetus was also confirmed by RT-PCR, strand-specific RT-PCR, real-time RT-PCR, and NASBA. INTERPRETATION: In addition to the lungs, H5N1 influenza virus infects the trachea and disseminates to other organs including the brain. The virus could also be transmitted from mother to fetus across the placenta. 太不幸了！又多了一种经血传播的疾病。传染病的防治任重而道远！:( :( 没有发现的传染病........传染病的防治任重而道远！！！
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