2012柳叶刀——亚洲南部和东南部社区获得性细菌血流感染：系统评价

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Community-acquired bacterial bloodstream infections in developing countries in south and southeast Asia: a systematic review

作者：Jacqueline Deen, Lorenz von Seidlein, Finn Andersen, Nelson Elle, Nicholas J White, Yoel Lubell
Menzies School of Health
Research, Casuarina, NT,
Australia (J Deen MD,
L von Seidlein PhD, F Andersen);
International Vaccine Institute,
Seoul, South Korea (N Elle MD);
Mahidol-Oxford Tropical
Medicine Research Unit,
Bangkok, Thailand
(Prof N J White MD,
Y Lubell PhD); and Centre for
Tropical Medicine, University
of Oxford, Oxford, UK
(Prof N J White, Y Lubell)
Correspondence to:
Dr Jacqueline Deen, Menzies
School of Health Research, Royal
Darwin Hospital Campus,
Casuarina, NT 0810, Australia
deen.jacqueline@gmail.com

出处：Lancet Infect Dis 2012;12: 480–87
Information about community-acquired bacteraemia in developing countries in south and southeast Asia is scarce. We
aimed to establish the case fraction of bacteraemia in febrile patients admitted to hospital. We searched four databases
and identifi ed studies of south and southeast Asia published between 1990 and 2010 that prospectively assessed patients
admitted to hospital and from whom a blood culture was taken. We reviewed 17 eligible studies describing 40 644 patients.
Pathogenic organisms were isolated from 3506 patients (9%; range 1–51%); 1784 (12%) of 14 386 adults and 1722 (7%)
of 26 258 children. Salmonella enterica serotype Typhi was the most common bacterial pathogen, accounting for 532 of
1798 (30%) isolates in adults and 432 of 1723 (25%) in children. Other commonly isolated organisms in adults were
Staphylococcus aureus, Escherichia coli, and other Gram-negative organisms, and in children were Streptococcus
pneumoniae and Haemophilus infl uenzae. A substantial case fraction of bacteraemia occurs in patients admitted to
hospital with fever in this region. Management could be improved if diagnostic microbiology facilities were more widely
available. The prevailing organisms causing bacteraemia and their susceptibility patterns could inform empirical
treatment regimens and prevention strategies.

影响因子：>15

晴天也飘雨

很好的文献。值得好好看一下

登山者

要开始学习血流感染了。。。。悲催。。。

鬼才

正好在学习血流感染相关知识，非常高兴见到这样好一篇综述文章，下载学习了。