肺炎链球菌结合疫苗不能影响急性中耳炎儿童携带金葡菌

David

Clinical Infectious Diseases 2007;45:1583–1587

BRIEF REPORT
Pneumococcal Conjugate Vaccine Does Not Influence Staphylococcus aureus Carriage in Young Children with Acute Otitis Media
肺炎链球菌结合疫苗不能影响急性中耳炎儿童携带金葡菌
Robert Cohen,1,2
Corinne Levy,2
Franck Thollot,3
France de La Rocque,2
Marc Koskas,2
Eric Bonnet,4
Bernard Fritzell,4 and
Emmanuelle Varon5

1Service de Microbiologie, Centre Hospitalier Intercommunal de Creteil, Creteil, and 2Association Clinique et Thérapeutique Infantile du Val de Marne, Saint Maur des Fossés, 3Association Française de Pédiatrie Ambulatoire, Essey les Nancy, 4Wyeth Pharmaceuticals France, La Defense, and 5National Reference Centre for Pneumococci, Assistance Publique–Hôpital de Paris, Hôpital Européen Georges Pompidou, Paris, France

Received 22 May 2007; accepted 7 August 2007; electronically published 12 November 2007.

Reprints or correspondence: Dr. Robert Cohen, Service de Microbiologie, Centre Hospitalier Intercommunal de Creteil, 40 Avenue de Verdun, F94 000 Créteil, France (robert.cohen@wanadoo.fr).
We investigated nasopharyngeal carriage of Streptococcus pneumoniae and Staphylococcus aureus among infants and young children with acute otitis media in a country where use of 7-valent pneumococcal conjugate vaccine (PCV7) has been progressively implemented. Among 1783 children enrolled, 60.8% carried S. pneumoniae, and 9% carried S. aureus. Among S. pneumoniae carriers, the rate of S. aureus carriage was 8.4%, compared with 9.9% among S. pneumoniae noncarriers. The rate of S. pneumoniae carriage in the PCV7-vaccinated population was lower (59.8%) than that observed in the nonvaccinated population (66.2%; ). In contrast, in young children (age, <2 years) with acute otitis media, our study suggests that the S. aureus carriage rate is not affected by PCV7 immunization (9.0% in vaccinated children vs. 8.7% in nonvaccinated children). Furthermore, in children aged >1 year, the booster dose induces a sharp reduction in the carriage of vaccine serotypes of S. pneumoniae, without any change in S. aureus carriage.