儿童ICU血流感染的危险因素（翻译有奖）

潮水

Factors Associated with Time to Acquisition of Bloodstream Infection in a Pediatric Intensive Care Unit
Infect Control Hosp Epidemiol 2010;31:249–255
Objective.To evaluate the risk factors that influence time to acquisition of a laboratory-confirmed bloodstream infection (LCBI).

Design.Prospective cohort study with an 18-month follow-up.

Setting.A 16-bed medical and/or surgical pediatric intensive care unit that cares for patients of the Brazilian Public Health System exclusively.

Patients.We included children from 0 to 18 years old who were represented by 875 consecutive admissions to the pediatric intensive care unit from January 1, 2005, through June 30, 2006. The children from all but 5 (0.6%) of the admissions were followed up until discharge or death. The majority (506 [58.2%]) were hospitalized for surgical pathology, and 254 (29.2%) underwent heart surgery.

Methods.We used a standardized questionnaire and data collection from daily charts. Information on risk factors was collected before the onset of first LCBI. Survival analysis was performed using the Kaplan-Meier method. The effect of the variables on the risk of LCBI each day was estimated through a Cox model fitting.

Results.Fifty-seven children (6.6%) developed an LCBI, 54 (94.7%) of whom made use of a central venous catheter. LCBI incidence was 11.27 episodes/1,000 patient-days and 17.92 episodes/1,000 patient-days when associated with a central venous catheter. Factors associated with time to the first LCBI in the Cox model were age less than 2 years (hazard ratio [HR], 1.99; 95% confidence interval [CI], 1.02–3.89), malnutrition (HR, 1.74; 95% CI, 1.01–3.00), use of a central venous catheter (HR, 4.36; 95% CI, 1.30–14.64), use of antibiotics before admission (HR, 0.58; 95% CI, 0.33–0.98), and use of transfused blood products (HR, 0.40; 95% CI, 0.22–0.74).

Conclusion.Factors associated with time to acquisition of LCBI were age less than 2 years, weight-for-age z score less than −2, and the use of a central venous catheter. Therefore, intensification of LCBI prevention efforts in patients with these characteristics is fundamental.

helena0506

回复 1# 潮水

水平有限，一点一点的翻译哈，可能有很多语法不对的，但是大概是这样的了：
为采集小儿重症监护室血流感染的相关因素与时间（感染控制流行病学杂志2010；31：249-255）
目的：评估影响实验室确诊血流感染的危险因素。
设计：18个月的前瞻性回顾
设置：来自独立的巴西公共卫生系统的十六张床病房或小儿外科重症监护病房
病人：我们选择包括从2005年1月1日至2006年6月30日的，具有代表性的0至18岁的875名患儿。有5个（占0.6%）将会离开或是死亡，大多数（占58.2%）会住院并且行外科病理诊断，有254个（占29.2%）将会实行心脏手术。
方法：我们用一种来自每日数据的标准问卷和数据收集。在第一个LCBI发病前危险因素的信息收集。用Kaplan-Meier 方法进行生存分析，每日影响LCBI的风险多种多样，通过COX模式被估计。
结果：有57个孩子（6.6%）发展成LCBI，有54个（占94.7%）运用了中心静脉导管。在结合运用中心静脉导管时，LCBI发作的发生率为11.27 /1000个病人每天，17.92/ 1,000个病人每天。在COX  模式中，对于第一个LCBI的与时间因素有关的小于两岁，（危险率用HR表示，1.99,95%，可信区间1.02-3.89，营养不良危险率1.74，95%，可信区间1.01-3.00，使用了中心静脉导管的危险率4.36.95%，可信区间1.30-14.64，使用血液制品输血，危险率0.4，可信区间0.22-0.74）
结论：获得LCBI的相关因素的年龄小于两岁，体重年龄比，值小于-2，和使用中心静脉导管。因此，加强预防病人中的LCBI是根本的。

helena0506

回复 1# 潮水

有啥子奖励啊？呵呵 ，我等到的哟，虽然翻译的不怎么对，还是尽了心的噻，要给奖励哈

绿茵场

回复 3# helena1982413
奖励肯定是有的哈，不知潮版的奖励力度，要不然我就代劳了，呵呵！
请耐心等待吧。

helena0506

回复 4# wen8023_绿茵场


要得，绿茵版主也一起奖励嘛，你看我们态度好端正哟。

潮水

回复 2# helena1982413
Fifty-seven children (6.6%) developed an LCBI
是57个儿童哦，57/（875-5）=6.6%
其他地方你再修改一下，还有奖励哦！

helena0506

回复 6# 潮水

哦，就是，你看我老糊涂的，呵呵！！！！！
我改不了了，英语水平有限，有些句子是复合句，太长了，我的翻译水平有限哈。大学毕业后就把英语给丢了。