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BMC Infect Dis. 2012 Sep 25;12(1):227. [Epub ahead of print]
A Prospective, Multicenter, Observational Study of Complicated Skin and Soft Tissue Infections in Hospitalized Patients: Clinical Characteristics, Medical Treatment, and Outcomes.Lipsky BA, Moran GJ, Napolitano LM, Vo L, Nicholson S, Kim M.
AbstractABSTRACT:
BACKGROUND: Complicated skin and soft tissue infections (cSSTIs) occur frequently, but limited data do not allow any consensus on an optimal treatment strategy. We designed this prospective, multicenter, observational study to to explore the current epidemiology, treatment, and resulting clinical outcomes of cSSTIs to help develop strategies to potentially improve outcomes.
METHODS: From June 2008 to December 2009 we enrolled a pre-specified number of adults treated in 62 U.S. hospitals with intravenous antibiotic(s) for any of the following cSSTIs: diabetic foot infection (DFI); surgical site infection (SSI); deep soft tissue abscess (DSTA); or, cellulitis. Investigators treated all patients per their usual practice during the study and collected data on a standardized form.
RESULTS: We enrolled 1,033 patients (DFI 27%; SSI 32%; DSTA 14%; cellulitis 27%; mean age 54 years; 54% male), of which 74% had healthcare-associated risk factors. At presentation, 89% of patients received initial empiric therapy with intravenous antibiotics; ~20% of these patients had this empiric regimen changed or discontinued based on culture and sensitivity results. Vancomycin was the most frequently used initial intravenous antibiotic, ordered in 61% of cases. During their stay 44% of patients underwent a surgical procedure related to the study infection, usually incision and drainage or debridement. The mean length of stay was 7.1 days, ranging from 5.8 (DSTA) to 8.1 (SSI).
文章说1033例患者，其中糖尿病足占27%、SSI占32%、深部软组织脓肿占14%、蜂窝组织炎占27%。有89%的患者经验性使用了静脉用抗菌药物，而20%根据培养及药敏结果调整或终止经验用药。万古霉素是起始使用最多的静脉用抗菌药物，处方比例占61%。44%的患者在住院期间因为研究的感染原因接受了手术治疗，常见的是切开引流或清创。平均住院天数为7.1天（5.8-8.1）
CONCLUSION: Our findings from this large prospective observational study that characterized patients with cSSTIs from diverse US inpatient populations provide useful information on the current epidemiology, clinical management practices and outcomes of this common infection.
虽然是预印本，但已经有全文了，新鲜得很呢
美国多中心复杂皮肤软组感染临床特点等研究.pdf
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发表于 2012-9-28 11:07
