【强烈推荐】美国CDC发布2012CRE防控指南
Appropriate hand hygiene tops the list of important practice measures for preventing the spread of carbapenem-resistant Enterobacteriaceae across health care facilities, according to guidelines issued by the CDC.See Also
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The guidelines expand on the 2009 CDC and Healthcare Infection Control Practices Advisory Committee recommendations. According to background information in the guidelines, carbapenem-resistant Enterobacteriaccae (CRE) has been associated with up to 40% to 50% mortality rates. Besides being resistant to carbapenem, CRE is also resistant to many other antimicrobials.
The CDC defines CRE as non-susceptible to carbapenems and resistant to the third-generation cephalosporins ceftriaxone, cefotaxime and ceftazidime. Currently, Klebsiella spp.and Escherichia coli that meet the definition of CRE are a priority for detection and containment.
“Since most carbapenem resistance mediated by carbapenemases in the United States is found among Klebsiella spp. and E. coli, individual facilities or public health authorities might choose to apply the CRE surveillance definition only to these specific Enterobacteriaceae,” the CDC wrote.
Awareness of CRE
For surveillance, inpatient facilities should be aware of whether CRE has ever been cultured from any of their patients and whether the cultures were obtained within 48 hours of the patient’s admission. The CDC recommends that facilities without the information perform evaluations to determine the incidence of CRE. In addition, the CDC recommends that facilities determine the epidemiology of patients with CRE, including information such as patient demographics, dates of admission, outcomes, medications and common exposures.
To prevent the spread of CRE, the CDC recommends that health care personnel follow appropriate hand hygiene measures. Not only should hand hygiene policies be in place, but hand hygiene practices should also be monitored, with adherence being reported to frontline staff.
The CDC also advises that health care facilities take contact precautions with patients who are infected or colonized with CRE. However, they do not have a firm recommendation for how long the patient should remain on contact precautions.
“Ensuring health care personnel are educated about the proper use and rationale for contact precautions is an important part of this process,” the CDC wrote. “In addition, facilities should ensure that there is a process to monitor and improve health care personnel adherence to contact precautions. This might include conducting periodic surveillance on the use of contact precautions and providing feedback to frontline staff about these results.”
Educating health care personnel
The CDC recommends that all health care personnel be educated in preventing the transmission of CRE. At minimum, the information they receive should include use of contact precautions and hand hygiene. Education is important for personnel at both acute and long-term care settings.
Minimizing device use is also recommended because these devices, such as central venous catheters, endotracheal tube and urinary catheters, pose a risk for device-associated infections. Device use should be monitored and discontinued and discarded properly.
Patients with CRE should be in single rooms or in rooms with other patients with CRE, in both acute and long-term care settings. In addition, laboratories are urged to have protocols to rapidly inform clinical staff and infection control staff when they identify CRE. Also, CRE screening is necessary among epidemiologically linked contacts of known CRE colonized or infected patients.
Lastly, antimicrobial stewardship programs should be in place, which ensure that “antimicrobials are used for the appropriate indications and duration and that the narrowest spectrum antimicrobial that is appropriate for the specific clinical scenario is used,” the CDC wrote.
References:
CDC. Guidance for control of carbapenem-resistant Enterobacteriaceae (CRE). Available at: http://www.cdc.gov/hai/pdfs/cre/CRE-guidance-508.pdf.
Perspective
http://www.healio.com/~/media/Images/Mugs/IDN/K/Kaye_Donald_web.ashx Donald Kaye
[*]Klebsiella pneumoniae carbapenase (KPC) is the most common carbapenemase found in the United States. Its distribution is spotty as it is common in some parts of the US but uncommon in others. Even in areas where KPC is frequently found, it is a common isolate in some health care settings and rarely found in others. It has been also reported in France, Colombia, Brazil, Israel, and China and in several species of enteric bacilli, most importantly Klebsiella pneumoniae and Escherichia coli, but also in Serratia marcescens, Klebsiella oxytoca, Citrobacter freundii, Enterobacter spp., and Salmonella enterica, and Pseudomonas aeruginosa.
Several other carbapenemases have been found in the United States but are much more common in other parts of the world, and are usually brought here after nosocomial exposure elsewhere. These carbapenemases include: New Delhi Metallo-beta-lactamase (NDM), Verona Integron-encoded Metallo-beta-lactamase (VIM) and Imipenemase (IMP) Metallo-beta-lactamase.
Carbapenemase-producing bacteria often contain genes that make them resistant to many other antimicrobial agents. The most reliably active antibiotics are the polymyxins and tigecycline.
[*]Donald Kaye, MD
[*]Infectious Disease News Editorial Board
麻烦高手翻译一下，这里90%以上的都看不懂{:1_17:} wxmsl 发表于 2012-7-16 18:19 static/image/common/back.gif
麻烦高手翻译一下，这里90%以上的都看不懂
这个事情管委会应该会有安排的。耐心等待吧{:1_3:} 蓝鱼o_0 发表于 2012-7-16 18:27 static/image/common/back.gif
这个事情管委会应该会有安排的。耐心等待吧
等待管委会通知，一定积极参与。 非常新的资料，CRE，耐碳青霉烯肠杆菌科细菌所引起的临床问题越来越严重，急需引起关注与重视！
感谢蓝鱼超版提供的最新资料。
哈哈，不好意思，我也看不太懂呀，盼译稿！{:1_1:} 多新鲜的东西！论坛的魅力！尽管我看不懂但是有好老师。等待！ 外语水平有限看不懂，有翻译版吗，谢谢！ 太牛逼了！
谢谢分享！！！！！！！！！！！！！！！！！{:1_12:} 金币用得太快，没有钱了！！！！！！！！！！！！！！！ 如何赚钱！！！！！！！！！！！！！！！！！！！！！！！！！！！！？？？？？？？？？？？？？？？？？？ 只好灌水了，我实在是太穷！没金币的日子不好过！！！！！！！！！！！！！！！！！ 下载学习，谢谢老师的奉献！ 灌水，没法子，求谅解 谢谢分享！努力学习中{:1_3:} 谢谢老师的分享！学习了！ 谢谢楼主分享，好资料！{:1_1:}{:1_1:}{:1_1:} 与现在的耐药菌趋势很契合，很有帮助 这个对于CRE防控来说 太有用了！！ 实在是太厉害了，要是有中文版的就更好了{:1_14:}
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