2012AAR环丙沙星耐药的E COLI，导致门诊病人UTI发生率增加
Recent study findings indicate that Escherichia coli antimicrobial-resistance to ciprofloxacin for urinary tract infections increased more than five-fold between 2000 and 2010.“Our study reveals that ciprofloxacin and trimethoprim-sulfamethoxazole are no longer safe for outpatient urinary tract infections,” Jose Bordon, MD, PhD, an infectious disease specialist at Providence Hospital, said in a press release. Bordon 说，对门诊病人UTI而言，环丙沙星和复方新诺明已经不再安全。
Bordon and colleagues from George Washington University and Providence Hospital in Washington, D.C. studied antimicrobial susceptibility data for urinary E. coli isolates obtained from outpatients between 2000 and 2010. The data were obtained from the Surveillance Network Database, which includes data from 200 institutions in the United States. The study included more than 12 million urinary E. coli isolates.
The greatest increase in resistance among the isolates was observed for ciprofloxacin, which showed a resistance rate of 3% in 2000 and a resistance rate of 17.1% in 2010. Resistance to trimethoprim-sulfamethoxazole increased from 17.9% in 2000 to 24.2% in 2010. Nitrofurantoin, amoxicillin-clavulanate and ceftriaxone only indicated small changes to resistance.
“Our study indicates that safer antimicrobials for outpatient urinary tract infections are nitrofurantoin in patients without kidney insufficiency and amoxicillin/clavulanate and third generation cephalosporins for all others,” Bordon said in the press release.
相对安全的是呋喃妥因，但是这类病人要排除肾功能不全。
References:
[*]Sanchez GV. Antimicrob Agents Chemother. 2012;56:2181-2183
Disclosures:
[*]The authors report no relevant financial disclosures
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