Ventilator associated pneumonia and transfusion, is there really an association?
Background: Anemic syndrome is a frequent problem in intensive care units. The most probableetiology is the suppression of the erythropoietin response due to the direct effects of cytokines, as
well as frequent blood sampling.
Transfusions are not free of complications, therefore transfusion reactions are estimated to occur
in 2% of the total packed red blood cells (pRBCs) transfused.
In the past several years, several trials had tried to compare the restrictive with the more liberal
use of transfusions, and they were found to be equally effective.
Nosocomial pneumonia is the most common nosocomial infection in intensive care units; the
prevalence is 47% with an attributive mortality of 33%.
There are multiple risk factors for the development of nosocomial pneumonia. Colonization of the
upper airways is the most important pathophysiological factor but there are other factors
implicated like, sedation techniques, inappropriate use of antibiotics and recumbent positioning.
A secondary analysis of the CRIT study describes transfusion therapy and its practices in the United
States. They found that transfusion practice is an independent risk factor for the development of
nosocomial pneumonia.
Methods: This is a multicenter, prospective cohort study in different intensive care units in
Colombia. A total of 474 patients were selected who had more than 48 hours of mechanical
ventilation.
The primary objective is to try to demonstrate the hypothetical relationship between the use of
transfusions and nosocomial pneumonia.
Secondly, we will try to determine which other factors are implicated in the development of
pneumonia in intensive care units and describe the incidence of pneumonia and transfusion
practices.
Discussion: Ventilator associated pneumonia is a primary problem in the intensive care unit,
multiple factors have been associated with its presence in this study we try to explore the possible
association between pneumonia and transfusion, describe all other factors associated with this, and
the possible association with other nosocomial infections.
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