发现一个可以免费阅读的牛津大学期刊文献网站，贴一篇评价抗生素应用的，都有全文的哦
he Effect of Renal Dysfunction on Antimicrobial Use MeasurementsB. M. Zagorski1,
W. E. Trick4,
D. N. Schwartz2,3,
M. F. Wisniewski3,
R. C. Hershow1,
S. K. Fridkin4, and
R. A. Weinstein2,3
+ Author Affiliations
1University of Illinois at Chicago School of Public Health, Chicago, Illinois;
2Rush Medical College, Chicago, Illinois;
3Cook County Bureau of Health Services, Chicago, Illinois;
4Division of Healthcare Quality Promotion, National Center of Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia
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Abstract
The defined daily dose, a popular measurement of antimicrobial use, may underestimate the use of antimicrobials that are dose-adjusted in patients with renal insufficiency. To evaluate the effect of renal dysfunction on these measures, we performed a retrospective cohort study that involved patients receiving ceftriaxone, levofloxacin, or vancomycin, with use of defined daily doses and 2 methods based on therapy duration—stop-start days (i.e., entire therapy duration) and transaction days (i.e., unique therapeutic days). The vancomycin use rate for patients with renal insufficiency was 36% lower than that of patients with normal renal function for defined daily doses, and it was 23% lower for transaction days; for levofloxacin, there was a 27% rate reduction for the defined daily dose. No significant reduction was noted when the stop-start day method was used. Compared with the defined daily dose method, measures of therapy duration are less affected by renal function and may improve comparisons between populations.
以前论坛里就曾经推荐过，不过还是谢谢您热心的分享。{:1_17:} 太感谢了，一定会有用的。 oxford数据库更新后以前的文献就会免费放送的了。对于很新的文献，除非特别途径无法拿到全文。
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