放飞梦想 发表于 2012-2-25 06:42

术中聚维酮碘冲洗预防SSI-Meta分析

Title: Meta-analysis of intraoperative povidone-iodine application to prevent surgical-site infection
Author: Fournel, I.; Tiv, M.; Soulias, M. (...)
Source: Br J Surg, 2010, 97(11): 1603-1613
Abstract:
BACKGROUND: The effectiveness of intraoperative povidone-iodine (PVI) application in the reduction of surgical-site infection (SSI) remains controversial. This meta-analysis was performed to assess the effect of intraoperative PVI application compared with no antiseptic solution (saline or nothing) on the SSI rate. METHODS: The meta-analysis included randomized controlled trials that compared intraoperative PVI lavage with no PVI in patients undergoing surgery with SSI as the primary outcome. A fixed-effects or random-effects model was used as appropriate, and heterogeneity was assessed by the Cochran Q and the I(2) value. RESULTS: Twenty-four randomized controlled trials totalling 5004 patients (2465 patients with PVI and 2539 patients without) were included: 15 in the main analysis and nine in the sensitivity analysis. The rate of SSI was 8.0 per cent in the PVI group and 13.4 per cent in the control group. Intraoperative PVI application significantly decreased the SSI rate (relative risk 0.58, 95 per cent confidence interval 0.40 to 0.83; P = 0.003) and consistent results were observed in subgroup analyses according to the method of PVI administration, its timing and the type of surgery. CONCLUSION: The meta-analysis results suggested that the use of intraoperative PVI reduced rates of SSI.

细菌耐药 发表于 2012-2-25 07:21

"Intraoperative PVI application significantly decreased the SSI rate (relative risk 0.58, 95 per cent confidence interval 0.40 to 0.83; P = 0.003) "

That's interesting results.

放飞梦想 发表于 2012-2-25 11:28

细菌耐药 发表于 2012-2-25 07:21 static/image/common/back.gif
"Intraoperative PVI application significantly decreased the SSI rate (relative risk 0.58, 95 per cen ...

However， NICE guideline does not recommend PVI irrigation based on the rationale that PVI can only be used for intact skin.

shaverwoo 发表于 2012-3-16 11:49

放飞梦想 发表于 2012-2-25 11:28 static/image/common/back.gif
However， NICE guideline does not recommend PVI irrigation based on the rationale that PVI can onl ...

呵呵，挺有意思的，有原文上传吗，谢谢
页: [1]
查看完整版本: 术中聚维酮碘冲洗预防SSI-Meta分析