Prevention of CNS CVCRI using urokinase rinses
Prevention of Coagulase-Negative Staphylococcal Central Venous Catheter–Related Infection Using Urokinase Rinses: A Randomized Double-Blind Controlled Trial in Patients With Hematologic MalignanciesPrevention of CNS CVCRI using urokinase rinses
【摘要】
Purpose
Fibrin deposition at the intraluminal surface of the indwelling part of the central venous catheter
(CVC) surface increases the risk of CVC-related coagulase-negative staphylococci (CoNS) infection.
Therefore, repetitive enzymatic dissolution of fibrin by urokinase might reduce the risk of
CVC-related infection. We undertook this study to investigate whether three times weekly
urokinase rinsing of CVC reduces the incidence or severity of CVC-related infections by CoNS in
patients undergoing intensive cytotoxic treatment for hematologic malignancies.
Patients and Methods
In a double-blind setting, all consecutive patients with a CVC were randomly allocated to receive
either urokinase rinses (5 mL of 5,000 U/mL) or placebo (saline), both three times weekly.
Results
The percentage of patients with at least one positive culture with CoNS was lower in patients
receiving urokinase compared with patients receiving placebo (26% v 42%, respectively; relative
risk 0.61; 95% CI, 0.39 to 0.94). Major CVC-related CoNS infection occurred less frequently
in patients receiving urokinase versus placebo (1.2% v 14.1%, respectively; RR 0.09; 95% CI,
0.01 to 0.50). Secondary complications, including CVC-related thrombosis, were observed less
frequently in the urokinase group compared with the placebo group (1.3% v 9.0%, respectively;
RR 0.14; 95% CI, 0.02 to 0.82). No severe bleeding complications attributable to urokinase
were observed.
Conclusion
Three times weekly urokinase rinsing reduces the incidence of CVC-related CoNS infection in
patients treated with intensive cytotoxic therapy for hematologic malignancies, with acceptable
safety.
很感兴趣的一个内容，以前没有看过这方面的文献，应用尿激酶预防导管相关性血流感染，先下载了再慢慢学。谢谢了哦！ liuxingyu6 发表于 2011-10-29 01:07 static/image/common/back.gif
很感兴趣的一个内容，以前没有看过这方面的文献，应用尿激酶预防导管相关性血流感染，先下载了再慢慢学。谢 ...
JCO杂志大家可能不太熟悉，而往往是NATURE, CELL，LANCET，NJEM等大家比较了解些。
JCO和JCI是临床医学中的顶级杂志。分值大概在17分左右。所以他的研究非常有参考价值，细节方面也非常好。图表，文字，甚至是参考文献和致谢都让人赏心悦目！ 蓝鱼老师，JCO、JCI有电子版免费杂志不？如有麻烦给个网址。不甚感谢！ liuxingyu6 发表于 2011-10-29 01:28 static/image/common/back.gif
蓝鱼老师，JCO、JCI有电子版免费杂志不？如有麻烦给个网址。不甚感谢！
没有的。国外的杂志大部分都是要付费的。只有有些数据库的杂志会在一段时间后释放。 蓝鱼o_0 发表于 2011-10-29 09:06 static/image/common/back.gif
没有的。国外的杂志大部分都是要付费的。只有有些数据库的杂志会在一段时间后释放。
那些数据库的杂志会再一段时间后释放呢？ 比较多，比如OXFORD的数据库。还有HIGHWIRE。PUBMED里面可以选择有全文的文献下载。
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