81# create_qiao
2，3有，1 没有
David版主，帮我再查找3篇论文，谢谢！;P
1、Pneumonia in long-term care: a prospective case-control study of risk factors and impact on survival.
Vergis,ENBrennen,CWagener,MMuder,RR
Archives of Internal Medicine
2001V.161,no.19,2001("")
2、The impact of catheter-restricted filling with cefotaxime and heparin on the lifespan of temporary hemodialysis catheters: a case controlled study.
J Nephrol.2005; 18(6):755-63 (ISSN: 1121-8428)
3、An outbreak of invasive aspergillosis among allogeneic bone marrow transplants: a case-control study
Infect Control. 1985 Sep;6(9):347-55
82# David
收到，谢谢
83# 楚楚
1有，2，3没有
求助文献两篇
1: Water Sci Technol. 2005;52(8):15-28.
Resistance of Legionella to disinfection in hot water distribution systems.
Saby S, Vidal A, Suty H.
2: Water Sci Technol. 2004;50(1):77-82.
Biofilms, thermophilic amoebae and Legionella pneumophila--a quantitative risk assessment for distributed water.
Storey MV, Ashbolt J, Stenström TA
To gaoxd5:
Journal of Infection and Public Health
Volume 1, Issue 2, 2008, Pages 62-71
Review
The impact of U.S. policies to protect healthcare workers from bloodborne pathogens: The critical role of safety-engineered devices
Janine Jaggera, Jane Perrya, , , Ahmed Gomaab and Elayne Kornblatt Phillipsa
aInternational Healthcare Worker Safety Center, Division of Infectious Diseases, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
bDivision of Surveillance Hazard Evaluation and Health Studies, National Institute for Occupational Safety and Health, U.S. Centers for Disease Control and Prevention, Cincinnati, OH, USA
Received 2 October 2008;revised 16 October 2008;accepted 17 October 2008.Available online 26 November 2008.
Summary
In the United States (U.S.), federal legislation requiring the use of safety-engineered sharp devices, along with an array of other protective measures, has played a critical role in reducing healthcare workers’ (HCWs) risk of occupational exposure to bloodborne pathogens over the last 20 years. We present the history of U.S. regulatory and legislative actions regarding occupational blood exposures, and review evidence of the impact of these actions. In one large network of U.S. hospitals using the Exposure Prevention Information Network (EPINet) sharps injury surveillance program, overall injury rates for hollow-bore needles declined by 34%, with a 51% decline for nurses. The U.S. experience demonstrates the effectiveness of safety-engineered devices in reducing sharps injuries, and the importance of national-level regulations (accompanied by active enforcement) in ensuring wide-scale availability and implementation of protective devices to decrease healthcare worker risk.
Keywords: Needlestick injuries/sharps injuries; Occupational exposures; Safety-engineered sharp devices; Bloodborne pathogens regulations; Healthcare worker safety
86# 叹息之墙
No fulltext, sorry~
本帖最后由 gjs661 于 2009-10-13 21:42 编辑
David版主请帮忙查:
Lin TY，Chang LY，Huang YC，et al .Different proinflammatory reactions in fatal and non-fatal enterovirus 71 infections：implications for early recognition and therapy．Acta Paediatr，2002，91(6)：632-635
谢谢！
89# gjs661
Acta Pædiatrica
Volume 91 Issue 6, Pages 632 - 635
Published Online: 2 Jan 2007
Different proinflammatory reactions in fatal and non-fatal enterovirus 71 infections: implications for early recognition and therapy
T-Y Lin 1 , L-Y Chang 1 , Y-C Huang 1 , K-H Hsu 2 , C-H Chiu 1 K-D Yang 1
1 Division of Pediatric Infectious Diseases, Department of Pediatrics1, Chang Gung Children's Hospital, Linkou and Kaohsiung 2 Department of Health Care Management, Chang Gung University Medical College, Taoyuan, Taiwan
Correspondence toLuan-Yin Chang Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung University, 5 Fu-Hsin Street, Kwei-Shan Hsiang, Taoyuan County, Taiwan (Tel. +886 3 3281 200 ext. 8002, fax. +886 3 3288 957, e-mail. ly7077@tpts6.seed.net.tw)
Copyright 2002 Taylor & Francis
KEYWORDS
Brainstem encephalitis • cytokine storm • enterovirus 71 • interleukin 6 • pulmonary oedema
ABSTRACT
Aim: The mechanism of pulmonary oedema, a life-threatening manifestation of enterovirus 71 (EV71) encephalitis, is unclear. Our aim was to assess the relationship of proinflammatory cytokines to EV71-related pulmonary oedema. Methods: Proinflammatory responses in 33 EV71 patients with various complications and 21 normal healthy children were measured using an enzyme-linked immunosorbent assay. Results: EV71 patients with both encephalitis and pulmonary oedema were found to have much higher levels of blood interleukin-6 (IL-6) (947 ± 1239 vs 4.9 ± 3.1 pg/ml, p= 0.0003), tumour necrosis factor-α (TNF-α) (22.4 ± 29.5 vs 5.3 ± 1.0 pg/ml, p= 0.0035), interleukin 1β (IL-1β) (48.4 ± 85.2 vs 4.9 ± 10.1 pg/ml, p= 0.01), white blood cell count (28.3 ± 7.6 vs 15.5 ± 6.8 109/L, p± 0.0001) and blood glucose (501 ± 186 vs 165 ± 117 mg/dL, p= 0.0009) than patients with EV71 encephalitis alone. In fact, the cytokine levels in patients with encephalitis only or in those without complications were not significantly different from the levels found in normal children. The sensitivity, specificity, positive and negative predictive values of IL-6 < 70 pg/ml for EV71 encephalitis with pulmonary oedema were all 100%.
Conclusion: Patients with EV71-related encephalitis combined with pulmonary oedema were found to have significantly elevated levels of proinflammatory cytokines and the best predictor for this complicated condition was found to be the level of serum IL-6.
--------------------------------------------------------------------------------
Received Oct. 24, 2001; revision received Feb. 8, 2002; accepted Feb. 19, 2002
90# David
收到，辛苦了，谢谢您！
再麻烦您，查查这个：
Wang SM，Lei HY，Huang MC，et al .Modulation of cytokine production by intravenous immunoglobulin in patients with enterovirus 71-associated brainstem encephalitis．J Clin Virol，2006，37(1)：47—52．
92# gjs661
Journal of Clinical Virology
Volume 37, Issue 1, September 2006, Pages 47-52
Modulation of cytokine production by intravenous immunoglobulin in patients with enterovirus 71-associated brainstem encephalitis
Shih-Min Wanga, c, Huan-Yao Leid, Mei-Chih Huange, Ling-Yao Sub, d, Hui-Chen Linb, Chun-Keung Yud, Jung-Lung Wangb and Ching-Chuan Liub, ,
aDepartment of Emergency Medicine, National Cheng Kung University & Hospital, 138 Sheng Li Road, 70428 Tainan, Taiwan
bDepartment of Pediatrics, National Cheng Kung University & Hospital, 138 Sheng Li Road, 70428 Tainan, Taiwan
cInstitute of Clinical Medicine, National Cheng Kung University, 1 Ta-Hsueh Road, 70101 Tainan, Taiwan
dDepartment of Microbiology & Immunology, National Cheng Kung University, 1 Ta-Hsueh Road, 70101 Tainan, Taiwan
eDepartment of Nursing, National Cheng Kung University & Hospital, 138 Sheng Li Road, 70428 Tainan, Taiwan
Received 1 September 2005;revised 16 February 2006;accepted 26 May 2006.Available online 24 July 2006.
Abstract
Background
Several epidemics of enterovirus 71 (EV71) infections occurred in Taiwan since 1998.
Objectives
We performed the study to determine the changes in cytokine profiles associated with administration of intravenous immunoglobulin (IVIG) in patients with EV71-associated brainstem encephalitis complicated by autonomic nervous system (ANS) dysfunction and pulmonary edema.
Study design
Plasma cytokine concentrations (IL-1β, IL-6, IL-8, IFN-γ, TNF-α, IL-2, IL-4, IL-5, IL-10, and IL-13) were monitored on admission and within 12–24 h after administration of IVIG in a cohort of children (n = 22) with virologically confirmed EV71 infection, from March 2000 through April 2004.
Result
Plasma levels of IFN-γ, IL-6, IL-8, IL-10, and IL-13 levels significantly decreased in patients with pulmonary edema after administration of IVIG, P < 0.05. Plasma levels of IL-6 and IL-8 were significantly decreased in patients with ANS dysregulation after administration of IVIG, P < 0.05. Administration of IVIG was not associated with significant changes in plasma concentration of IL-1β, IL-2, IL-4, IL-5 IL-10, IL-13 and TNF-α in patients with ANS dysregulation.
Conclusions
These findings suggest that IVIG might be considered to have a therapeutic role in EV71-associated brainstem encephalitis. A clinical trial is needed to support this hypothesis.
Keywords: Cytokine; Enterovirus 71; IVIG; Pulmonary edema
93# David
给您添麻烦啦，帮了大忙。真是太感谢您了！
本帖最后由 gjs661 于 2009-10-21 08:23 编辑
再查5两篇相关文章：
1.Hsueh c，Jung SM，Shih SR，et a1．Acute encephalomyelitis during an outbreak of enterovirus type 71 infection in Taiwan：report of all autopsy cace with pathologic，immunofluorescenee，and molecular studies．Mod Pathol，2000，13：1200—1205．
2.Wang SM，Lei HY，Huang KJ，et a1．Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients：roles of eytokines and cellular
immune activation in patients with pulmonary edema J Infec Dis，2003。188：564-570．
3.Wu JM，Wang JN，Tsai YC，et a1．Cardiopulmonary manifestations of fulminant entemvims 71 infection．Pediatrics，2002，109：l-5．
4.Kao SJ，Yang F1L，I-Isu YH，et a1．Mechanism of fulminant pulmonary edema caused by enterovirus 71．Clin Infect Dis，2004，38：1784-1788．
5.Lin TY，Hsia SH，Huang YC．et a1．Proinflammatory Cytokine Reactions in Enterovirus 7 l Infections of the Central Nervous System ．Clin Infect Dis，2003，36(3)：269—274．
95# gjs661
96# David
千言万语汇成两个字：谢谢！:handshake
还需要麻烦您，请查找：
1.Chen KT，Chang HL，Wang ST，et a1．Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 7l in Taiwan，1998—2005．Pediatrics，2007，120(2)：e244—252．
2Chang LY，Hsiung CA，Lu CY，et alStatus of cellular rather than humora1 imnm nity is correlated with clinicaI outcome of enterovirus 71 Pediat7-Res，2006，60(4)：466—471
3.Wang SM，Lei HY，Huang MC，et a1．Therapeutic efficacy of milrinone in the management of enterovirus 7l-induced pulmoIlary edema．Pediatr Pulmonol，2005，39(3)：219-223．
4.31] Tsou YA，Cheng YK，Chung HK，et al Upper aerodigestive tract sequelae in severe enterovirus 7 1 infection：predictors and outcome lnt JPediatrOtorhinolaryngol，2008，72(1)：41—47
5.Wang SM,Lei HY,et al Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitisand echovirus meningitis infections of varying severity Clin
Microbiol Infect ,2007,13(7)：677—682．
98# gjs661
再次感谢David 版主，这几篇看完可能还要麻烦您！:lol
麻烦这一篇能否找到：
Tsao KC, Chan EC, Chang LY, Chang PY, Huang CG, Chen YP, Chang SC, Lin TY, Sun CF, Shih SR 2002 Responses of IgM for enterovirus 71 infection.
J Med Virol 68:574–580