Evidence for the cure of HIV infection by CCR5{Delta}32
本帖最后由 majiarui 于 2011-6-8 19:18 编辑Allers K , Hütter G , Hofmann J , Loddenkemper C , Rieger K , Thiel E , Schneider T .
Department of Gastroenterology, Infectious Diseases, and Rheumatology, Medical Clinic I, Campus Benjamin Franklin, Charité-University Medicine Berlin, Berlin, Germany;
Abstract
HIV entry into CD4(+) cells requires interaction with a cellular receptor, generally either CCR5 or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral replication remained absent despite discontinuation of antiretroviral therapy after transplantation with CCR5Δ32/Δ32 stem cells. However, it was expected that the long-lived viral reservoir would lead to HIV rebound and disease progression during the process of immune reconstitution. In the present study, we demonstrate successful reconstitution of CD4(+) T cells at the systemic level as well as in the gut mucosal immune system after CCR5Δ32/Δ32 stem cell transplantation, while the patient remains without any sign of HIV infection. This was observed although recovered CD4(+) T cells contain a high proportion of activated memory CD4(+) T cells, ie, the preferential targets of HIV, and are susceptible to productive infection with CXCR4-tropic HIV. Furthermore, during the process of immune reconstitution, we found evidence for the replacement of long-lived host tissue cells with donor-derived cells, indicating that the size of the viral reservoir has been reduced over time. In conclusion, our results strongly suggest that cure of HIV has been achieved in this patient.
PMID: 21148083
全球首个艾滋病治愈病例出现：美国人蒂莫西·雷·布朗同时患有白血病和艾滋病。2007年，他的病情恶化，主治医生胡特决定为他进行骨髓移植，先治白血病。结果，这次移植竟治愈了艾滋病。这一进展发表在权威医学杂志《Blood》上
http://pubmed.cn/21148083 有点神奇，那么是否可以认为在现代医学中，我们国家也可以这么治呢？或者是说，通过换骨髓的方法来治愈艾滋病呢。 带来希望，前途艰难！
希望：{:1_12:}
Cells of persons homozygous for the CCR5 gene variant Δ32 (CCR5Δ32/Δ32) are naturally resistant to infection with CCR5-tropic HIV strains (R5 HIV) ...
艰难：{:1_11:}
1、...The absence of the CCR5 wild-type gene variant in donor cells provided us with the possibility to discriminate between donor- and host-derived immune cells...
2、...These findings argue for the absence of HIV disease progression in the largest component of the lymphoid organ system...
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