金黄色葡萄球菌的基因谱进化趋势
FEMS Microbiol Rev. 2007 Nov 5;Evolution and pathogenesis of Staphylococcus aureus: lessons learned from genotyping and comparative genomics.
Feng Y, Chen CJ, Su LH, Hu S, Yu J, Chiu CH.
James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou, China.
Staphylococcus aureus is an opportunistic pathogen and the major causative agent of numerous hospital- and community-acquired infections. Multilocus sequence typing reveals a highly clonal structure for S. aureus. Although infrequently occurring across clonal complexes, homologous recombination still contributed to the evolution of this species over the long term. agr-mediated bacterial interference has divided S. aureus into four groups, which are independent of clonality and provide another view on S. aureus evolution. Genome sequencing of nine S. aureus strains has helped identify a number of virulence factors, but the key determinants for infection are still unknown. Comparison of commensal and pathogenic strains shows no difference in diversity or clonal assignments. Thus, phage dynamics and global transcriptome shifts are considered to be responsible for the pathogenicity. Community-acquired methicillin-resistant S. aureus (C-MRSA) is characterized by a short SCCmec and the presence of a Panton-Valentine leukocidin locus, but no studies have proven their exact biologic roles in C-MRSA infection, indicating the existence of other mechanisms for the genesis of C-MRSA.
回复 #1 David 的帖子
好象在9月份的两岸三地的学术交流会上,王辉就是讲了这个题目的. Feng Y, Chen CJ, Su LH, Hu S, Yu J, Chiu CH这几个人是谁呀?能告诉他们的中文名字吗?
回复 #3 巴斯德之徒 的帖子
嘿嘿，这很重要吗？:lol回复 #4 ttmm 的帖子
对!有时间去套套近乎呀!呵呵.......没有谈资,人家说不定会把我当疯子的!;P ;P 感谢老师分享！！！！！！！！！！！！！！！！1
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