幽门螺杆菌知多少？
文献来源：Miao,R, Wan, C, Wang, Z.The relationship of gastric microbiotaand Helicobacter pylori infection in pediatricspopulation. Helicobacter.2020; 25:e12676. https://doi.org/10.1111/hel.12676Background:Inrecent years, the impact of Helicobacter pylori (H pylori)on the gut microbiota has attracted more attention; however, the relationshipin pediatric population rarely was reported.背景：近年来，幽门螺杆菌（H-pylori）对肠道菌群的影响越来越引起人们的关注，但在儿科人群中这种关系却鲜有报道。Methods:Endoscopicgastric mucosal biopsy specimens from 55 children with gastrointestinalsymptoms were collected, 37 of them were H pylori‐positive (23nonpeptic ulcer and 14 peptic ulcer) and 18 were H pylori‐negative.In addition, 11 specimens were collected from H pylori‐ positivechildren who performed second endoscopy in 4 weeks after therapy.Microbial abundance and compositions were analyzed by 16S ribosomal RNAamplification and microbial functions were predicted using the softwarePICRUSt.方法：收集55例胃肠道症状患儿的内镜胃黏膜活检标本，其中幽门螺杆菌阳性37例（非消化性溃疡23例，消化性溃疡14例），幽门螺杆菌阴性18例。此外，还从治疗后4周内进行第二次内镜检查的幽门螺杆菌阳性儿童中收集了11个标本。通过16S核糖体RNA扩增分析微生物的丰度和组成，并使用PICRUSt软件预测微生物的功能。
Results:Thegastric microbiota of H pylori‐ positive children weremainly dominated by Helicobacter in genus (95.43%). Themicrobiota richness and diversity of H pylori‐ positivechildren were lower than that of H pylori‐ negativechildren. No difference was found in microbiota structure between H pylori‐ positivechildren with or without peptic ulcer. The richness and compositions aftertherapy were closer to the characteristics of H pylori‐ negativechildren. For predicted functions, higher abundance in pathways of infectiondiseases, cancer and lower abundance in the pathways of amino acid, lipid, andcarbohydrate metabolism were found in H pylori‐ positivegroup than H pylori‐ negative group.结果：幽门螺杆菌阳性儿童胃内微生物群主要为属内的幽门螺杆菌（95.43%）。幽门螺杆菌阳性儿童的微生物群落丰富度和多样性低于幽门螺杆菌阴性儿童。有或没有消化性溃疡的幽门螺杆菌阳性儿童之间的微生物群结构没有发现差异。治疗后的丰富度和成分更接近幽门螺杆菌阴性儿童的特点。对于预测的功能，幽门螺杆菌阳性组的感染疾病、癌症的途径中的丰度较高于幽门螺杆菌阴性组，而氨基酸，脂质和碳水化合物代谢途径中的丰度较低于幽门螺杆菌阴性组。
Conclusion:Thecharacteristics of gastric microbiota were affected by H pylori infectionrather than disease states, and the richness and diversity of gastric specieswere inverse correlation with H pylori infection inchildren. Eradication therapy was helpful to restore shifted gastricmicrobiota.结论：胃菌群特征受幽门螺杆菌感染的影响，而不是疾病状态；胃菌群的丰富性和多样性与儿童幽门螺杆菌感染呈负相关。根除疗法有助于恢复移位的胃微生物群。
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