新生儿ICU粘质沙雷氏菌暴发感染：被污染的液体肥皂和风险因素

David

Journal of Hospital Infection
Volume 72, Issue 1, May 2009, Pages 17-22

Outbreak of Serratia marcescens in a neonatal intensive care unit: contaminated unmedicated liquid soap and risk factors
新生儿ICU粘质沙雷氏菌暴发感染：被污染的液体肥皂和风险因素

S. Buffet-Bataillona, , , V. Rabierb, P. Bétrémieuxb, A. Beuchéeb, M. Bauera, P. Pladysb, E. Le Gallb, M. Cormiera, c and A. Jolivet-Gougeonc

aUnité d’Hygiéne Hospitaliére, Póle Microorganismes, CHU Pontchaillou, Rennes, France

bDépartement de Médecine de I‘Enfant et de I’Adolescent, CHU Rennes, France

cEquipe Microbiologie, UPRES-EA 1254, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes 1, Université Européenne de Bretagne, Rennes, France


Received 26 February 2008;  accepted 5 January 2009.  Available online 25 February 2009.

Summary
This study describes an outbreak of Serratia marcescens and its investigation and control in a neonatal intensive care unit (NICU). During a three-month period, five infants were colonised or infected by a single strain of S. marcescens. A case–control study, culture surveys and pulse-field gel electrophoresis analysis implicated a bottle soap dispenser as a reservoir of S. marcescens (P = 0.032). Infants with S. marcescens colonisation or infection were also more likely to have been exposed to a central or percutaneous venous catheter (P = 0.05) and had had longer exposure to endotracheal intubation (P = 0.05). Soap dispensers are used in many hospitals and may be an unrecognised source of nosocomial infections. This potential source of infection could be reduced by using ‘airless’ dispensers which have no air intake for the distribution of soap. Prompt intervention and strict adherence to alcoholic hand disinfection were the key factors that led to the successful control of this outbreak.

Keywords: Case–control study; Neonate; Serratia marcescens; Soap

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A case–control study, culture surveys 可翻译为病例对照研究和病原检测，供参考。