CRE感染的治疗（全文已经有啦，见楼下）
非常遗憾，我现在还是无法上传附件，否则可以分享全文给大家。看到2014年新出来的一篇CRE综述，讲的是目前CRE感染治疗的EVIDENCE，总结的挺好。
只能在这里贴出ABSTRACT。
Antibiotic Treatment of Infections Due to Carbapenem-Resistant Enterobacteriaceae: Systematic Evaluation of the Available Evidence
Matthew E. Falagas,a,b,c Panagiota Lourida,a Panagiotis Poulikakos,a,b Petros I. Rafailidis,a Giannoula S. Tansarlia
Alfa Institute of Biomedical Sciences (AIBS), Marousi, Athens, Greecea; Department of Internal Medicine, Infectious Diseases, Mitera Hospital, Hygeia Group, Athens,
Greeceb; Tufts University School of Medicine, Boston, Massachusetts, USAc
We sought to evaluate the effectiveness of the antibiotic treatment administered for infections caused by carbapenemase-producing
Enterobacteriaceae. The PubMed and Scopus databases were systematically searched. Articles reporting the clinical outcomes
of patients infected with carbapenemase-producing Enterobacteriaceae according to the antibiotic treatment administered
were eligible. Twenty nonrandomized studies comprising 692 patients who received definitive treatment were included.
Almost all studies reported on Klebsiella spp. In 8 studies, the majority of infections were bacteremia, while pneumonia and urinary
tract infections were the most common infections in 12 studies. In 10 studies, the majority of patients were critically ill.
There are methodological issues, including clinical heterogeneity, that preclude the synthesis of the available evidence using statistical
analyses, including meta-analysis. From the descriptive point of view, among patients who received combination treatment,
mortality was up to 50% for the tigecycline-gentamicin combination, up to 64% for tigecycline-colistin, and up to 67% for
carbapenem-colistin. Among the monotherapy-treated patients, mortality was up to 57% for colistin and up to 80% for tigecycline.
Certain regimens were administered to a small number of patients in certain studies. Three studies reporting on 194 critically
ill patients with bacteremia showed individually significantly lower mortality in the combination arm than in the monotherapy
arm. In the other studies, no significant difference in mortality was recorded between the compared groups.
Combination antibiotic treatment may be considered the optimal option for severely ill patients with severe infections. However,
well-designed randomized studies of specific patient populations are needed to further clarify this issue.
可以乔斑还上传啦附近。 我帮鱼管传吧{:1_17:} 乔-乔 发表于 2014-9-27 22:22
我帮鱼管传吧
{:1_17:}太好了！ 终于找了台电脑能上传附件，不容易啊啊。
估计是不是WINDOW 7才行。
家里的电脑是XP，32位操作系统，所以弄不了。
上传全文，大家下载吧。
AAC，微生物的专家和药剂科的老师应该不陌生，影响力不小的老牌SCI期刊。
星火 发表于 2014-9-27 22:05
可以乔斑还上传啦附近。
俺们已经搞定了，嘻嘻。找了台电脑。 蓝鱼o_0 发表于 2014-9-28 10:26
终于找了台电脑能上传附件，不容易啊啊。
估计是不是WINDOW 7才行。
感谢感谢，学习一下，正好需要
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