未感染和VRE感染患者同居一室，感染风险多少呢？
住院时，如果临床病友有MDRO定植，如VRE；那么他发生获得性VRE（定植或者感染）的概率为多少？前瞻性随访研究发现，这个危险度能达到17倍以上。
所以在MDRO防控指南中特别提到了要cohort患者，想必这也是重要原因。
循证证据如下：
Impact of chlorhexidine-impregnated washcloths on reducing incidence of vancomycin-resistant enterococci colonization in hematologyeoncology patients
Pauline Bass RN, BSc a, Surendra Karki MSc, MIH, DipVac b, Deborah Rhodes RNa, Susan Gonelli RNc,
Gillian Land RNa, Kerrie Watson MSc a, Denis Spelman MBBS, MPH, FRACP, FRACPAd,
Glenys Harrington RNe, Jacqueline Kennon RN, GradDip (Clin Epi) a,
Allen C. Cheng PhD, MBBS, MPH, FRACP b,*
Background: Daily skin cleansing with washcloths impregnated with chlorhexidine gluconate (CHG) of
patients in intensive care unit is associated with reduction in incidence of vancomycin-resistant
Enterococci (VRE) acquisition. This study describes the impact on incidence of VRE colonization after
the implementation of daily skin cleansing with 2% CHG-impregnated washcloths in hematologye
oncology patients.
Methods: In this before-and-after study, we compared the incidence rate of VRE colonization during the
baseline period (where routine soap-and-water bathing was used) with the intervention period where
patients were cleansed with 2% CHG-impregnated washcloths.
Results: Acquisition of VRE decreased from 7.8% in the baseline to 3.8% in the intervention period
(relative risk, 0.48, 95% confidence interval , 0.21-1.09; P ¼ .07). The crude relative rate of acquisition
during the intervention period compared with the baseline period was 0.53 (95% CI, 0.23-1.23; P ¼ .13).
Patients who had been a roommate of a patient subsequently found to have VRE were at a significantly
increased risk for acquiring VRE (hazard ratio, 18.8, 95% CI, 5.37-66.15; P < .001). However, patients
admitted to the same bed number of previously known VRE-colonized patient were not at increased risk
of VRE acquisition (hazard ratio, 0.37, 95% CI, 0.11-1.22; P ¼ .10).
Conclusion: We did not observe a statistically significant reduction in the rate of VRE colonization in
association with the use of 2% CHG-impregnated washcloths among hematologyeoncology patients.
观看后很受启发！！！！！
多重耐药菌的循证工作在国内应该多多开展
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